Department of Surgery, Funabashi Municipal Medical Center, 1-21-1 Kanasugi, Chiba, 273-8588, Japan.
Division of Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY, 14263, USA.
Breast Cancer. 2018 Sep;25(5):614-618. doi: 10.1007/s12282-018-0865-5. Epub 2018 Apr 25.
Pseudocirrhosis is a rare hepatic complication of chemotherapy, which is morphological changes in hepatic contour that closely mimic cirrhosis. Like in classic cirrhosis, portal hypertension is common in patients with this condition. The mechanism of pseudocirrhosis is unknown to date. We report three cases of pseudocirrhosis arising in the setting of regression of breast cancer liver metastases. All the cases underwent systemic chemotherapy, and all had remarkable responses. Their hormone receptor statuses were all positive and Her2/neu statuses were all negative. They were all treated with cytotoxic chemotherapeutic agent and also hormone therapy. This report suggests clinicians should have pseudocirrhosis in mind when hormone therapy and cytotoxic chemotherapy are jointly administered.
假小叶性肝硬化是一种罕见的化疗后肝脏并发症，其肝脏轮廓的形态学改变与肝硬化非常相似。与经典肝硬化一样，此类患者常有门静脉高压。目前，假小叶性肝硬化的发病机制尚不清楚。我们报告了三例乳腺癌肝转移瘤消退时发生的假小叶性肝硬化。所有病例均接受全身化疗，且均有显著疗效。其激素受体状态均为阳性，Her2/neu 状态均为阴性。均接受细胞毒性化疗药物和激素治疗。本报告提示，当激素治疗和细胞毒性化疗联合应用时，临床医生应考虑到假小叶性肝硬化的可能。
