Derdau Volker
R&D, Integrated Drug Discovery, Isotope Chemistry and Metabolite Synthesis, Sanofi Germany, Frankfurt/Main, Germany.
J Labelled Comp Radiopharm. 2018 Dec;61(14):1012-1023. doi: 10.1002/jlcr.3630. Epub 2018 May 24.
In this review, newly developed cyanation methods are evaluated in regards to their usefulness in synthetic isotope chemistry. In combination with already established protocols in C- or C-isotope chemistry, this manuscript should help isotope scientists to choose the best possible method for their scientific cyanation problem, but with the main focus on C-applications. Perhaps, most promising of the described novel cyanation reaction is the decarboxylation-cyanation-hydrolysis approach which makes a 1-step late-stage functionalization procedure possible.
在本综述中，对新开发的氰化方法在合成同位素化学中的实用性进行了评估。结合碳或碳同位素化学中已有的方案，本手稿应有助于同位素科学家为其科学氰化问题选择最佳方法，但主要侧重于碳的应用。也许，所描述的新型氰化反应中最有前景的是脱羧-氰化-水解方法，它使一步后期官能团化过程成为可能。
