Affiliated Bayi Brain Hospital, The PLA Army General Hospital, Beijing, 100700, China.
Department of Neurology, Zhujiang Hospital, Guangzhou, 510282, China.
Cell Biol Int. 2018 Aug;42(8):1041-1049. doi: 10.1002/cbin.10980. Epub 2018 May 22.
The limited degree of functional recovery is closely associated with the condition of the periinfarct cortex after ischemic stroke. The model of oxygen-glucose deprivation in cultured neurons could partly simulate this condition. Proper dendritic morphology is crucial for the correct wiring of neuronal function. Hence, the question of how to facilitate the plasticity of neural dendrites is of great significance. DL-3-n-butylphthalide is an efficient medication for ischemic stroke. In this study, in addition to having neuroprotective effects, DL-3-n-butylphthalide could increase the number of primary and secondary dendrites and of dendritic tips as confirmed by Sholl analysis. This study further demonstrated that DL-NBP inactivates PI3K/AKT signaling to positively regulate dendritic branching.
功能恢复程度有限与缺血性脑卒中后梗死周围皮质的状况密切相关。培养神经元的氧葡萄糖剥夺模型可以部分模拟这种情况。适当的树突形态对于神经元功能的正确连接至关重要。因此，如何促进神经树突的可塑性具有重要意义。DL-3-正丁基苯酞是一种有效的缺血性脑卒中治疗药物。在这项研究中，除了具有神经保护作用外，DL-3-正丁基苯酞还可以增加初级和次级树突以及树突末梢的数量，这一点通过 Sholl 分析得到了证实。本研究进一步表明，DL-NBP 抑制 PI3K/AKT 信号通路，从而正向调节树突分支。
