Nuclear Medicine and Molecular Imaging Research Center, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran -
Nuclear Medicine and Molecular Imaging Research Center, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Q J Nucl Med Mol Imaging. 2020 Sep;64(3):321-325. doi: 10.23736/S1824-4785.18.03078-9. Epub 2018 Apr 26.
Although, different methods have been suggested on reducing salivary gland radiation after radioiodine administration, an effective preventive or therapeutic measure is still debated. To the best of our knowledge this is the second study that aimed to evaluate the effect of chewing-gum as a sialagogue on the radioiodine content of salivary gland, and radioiodine-induced symptoms of salivary gland dysfunction.
Twenty-two patients who were referred to radioiodine therapy were randomized into chewing-gum (group A) and control (group B) groups. Anterior and posterior planar images including both head and neck were obtained 2, 6, 12, 24 and 48 hours after the administration of radioiodine in all patients and round regions of interest (ROI) were drawn for both left and right parotid glands with a rectangular ROI in the region of cerebrum as the background. All patients were followed once, 6 months after radioiodine administration via a phone call for subjective evaluation of symptoms related to salivary gland damage.
There was no significant difference between the two groups regarding the mean age, gender and initial iodine activity. The geometric mean of background-corrected count per administrated dose and acquisition time was calculated for bilateral parotid glands. This normalized parotid count showed a significant reduction in net parotid count in both groups during the first 48 hours after the radioiodine administration. However, no significant difference was found between the groups according to the amount and pattern of dose reduction in this time period.
This study revealed that chewing-gum had no significant effect on the radioiodine content of parotid glands during the first 48 hours after radioiodine administration. Also, no significant difference was found in the incidence of relevant symptoms after 6 months comparing both groups.
尽管已经提出了多种方法来减少放射性碘治疗后唾液腺的辐射，但仍在争论有效的预防或治疗措施。据我们所知，这是第二项旨在评估咀嚼口香糖作为唾液腺分泌剂对唾液腺放射性碘含量以及放射性碘引起的唾液腺功能障碍症状的影响的研究。
22 名患者被随机分为口香糖组（A 组）和对照组（B 组），进行放射性碘治疗。在所有患者中，在给予放射性碘后 2、6、12、24 和 48 小时，获取包括头颈部在内的前后平面图像，并在左右腮腺区域绘制圆形感兴趣区（ROI），并在大脑区域绘制矩形 ROI 作为背景。所有患者在放射性碘治疗后 6 个月通过电话进行随访，评估与唾液腺损伤相关的症状的主观评估。
两组在平均年龄、性别和初始碘活度方面无显著差异。计算双侧腮腺的背景校正计数与每剂给药和采集时间的几何平均值。该归一化腮腺计数显示，在放射性碘给药后 48 小时内，两组的净腮腺计数均显著减少。然而，在该时间段内，两组之间的剂量减少量和模式没有发现显著差异。
本研究表明，在放射性碘给药后 48 小时内，咀嚼口香糖对腮腺的放射性碘含量没有显著影响。在 6 个月后比较两组，相关症状的发生率也没有显著差异。
