Upadhyaya Arun, Zhou Pingping, Meng Zhaowei, Wang Peng, Zhang Guizhi, Jia Qiang, Tan Jian, Li Xue, Hu Tianpeng, Liu Na, Wang Sen, Liu Xiaoxia, Wang Huiying, Zhang Chunmei, Zhao Fengxiao, Yan Ziyu, Wang Xiaoran, Zhang Xuemeng, Zhang Wan
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Nucl Med Commun. 2017 Nov;38(11):891-903. doi: 10.1097/MNM.0000000000000727.
This study aimed to examine the radioprotective effect of vitamin E on salivary glands after radioactive iodine (I) therapy in patients with differentiated thyroid cancer.
Eighty-two patients with differentiated thyroid cancer were enrolled in this study. They were divided randomly into four groups (control group: 22 cases, group A: 23 cases, group B: 22 cases, and group C: 15 cases) before postsurgical ablation therapy with 100 mCi I. The patients in groups A, B, and C received vitamin E 100, 200, and 300 mg/day orally, respectively, for a duration of 1 week before to 4 weeks after I therapy. Salivary gland function was assessed using salivary gland scintigraphy immediately before and 6 months after I therapy. Uptake fraction (UF), uptake index (UI), excretion fraction (EF), and excretion ratio (ER) of each salivary gland were measured and compared.
On comparison between before and after I therapy in the control group, there was a significant decrease in UF of both right and left parotid glands (all P<0.01). In group A, a significant increase in EF of the right parotid gland (P<0.01) and UI of the right submandibular gland (P<0.05) was found. In group B, there was a significant increase in UI of the right parotid gland and both submandibular glands (all P<0.01). In group C, there was a significant increase in UF of the left parotid gland (P<0.05) and the right submandibular gland (P<0.01). Also, there was a statistical increase in UI in both submandibular glands (all P<0.01). However, on comparing the changes in the post-I therapy salivary scintigraphy parameters among the four groups, there was a significant difference in ΔUI of the right parotid gland (P<0.05) and both submandibular glands (all P<0.01), as well as ΔER of the left parotid gland (P<0.05) and ΔUF of the left submandibular gland (P<0.05).
Vitamin E exerts significant protective effects on the parotid and submandibular glands after I therapy.
本研究旨在探讨维生素E对分化型甲状腺癌患者放射性碘（I）治疗后唾液腺的辐射防护作用。
82例分化型甲状腺癌患者纳入本研究。在术后用100mCi I进行消融治疗前，他们被随机分为四组（对照组：22例，A组：23例，B组：22例，C组：15例）。A、B、C组患者分别口服维生素E 100、200和300mg/天，从I治疗前1周持续至I治疗后4周。在I治疗前和治疗后6个月立即使用唾液腺闪烁扫描评估唾液腺功能。测量并比较各唾液腺的摄取分数（UF）、摄取指数（UI）、排泄分数（EF）和排泄率（ER）。
对照组I治疗前后比较，左右腮腺的UF均显著降低（均P<0.01）。A组中，右侧腮腺的EF显著增加（P<0.01），右侧下颌下腺的UI显著增加（P<0.05）。B组中，右侧腮腺和双侧下颌下腺的UI均显著增加（均P<0.01）。C组中，左侧腮腺的UF显著增加（P<0.05），右侧下颌下腺的UF显著增加（P<0.01）。此外，双侧下颌下腺的UI均有统计学意义的增加（均P<0.01）。然而，比较四组I治疗后唾液闪烁扫描参数的变化，右侧腮腺和双侧下颌下腺的ΔUI有显著差异（P<0.05），左侧腮腺的ΔER（P<0.05）和左侧下颌下腺的ΔUF（P<0.05）也有显著差异。
维生素E对I治疗后的腮腺和下颌下腺具有显著的保护作用。
