Parmaksız Elif Torun, Inal Ali, Salepci Banu, Comert Sevda, Fidan Ali, Kiral Nesrin, Doǧan Coşkun, Caglayan Benan
Department of Pulmonology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.
Department of Clinical Immunology, Baskent University, Istanbul Hospital, Istanbul, Turkey.
Lung India. 2018 May-Jun;35(3):199-203. doi: 10.4103/lungindia.lungindia_11_17.
Asymmetric dimethylarginine (ADMA) has emerged as a risk marker for many conditions related to pulmonary hypertension (PH); however, little is known about ADMA and symmetric dimethylarginine (SDMA) plasma concentrations in chronic obstructive pulmonary disease (COPD). Our interest centers on the role of ADMA in regulation of endothelial function in COPD and secondary PH. The aim of the present study was to evaluate the serum ADMA, SDMA, and L-arginine concentrations in COPD and its association with PH.
Patients with diagnosis of COPD underwent pulmonary function tests, echocardiography, and laboratory investigations including ADMA, SDMA, and L-arginine.
Serum concentrations of ADMA, SDMA, and L-arginine tend to increase as COPD progresses. Patients with PH had higher concentrations of ADMA, SDMA, and L-arginine compared to cases with normal pulmonary arterial pressure (PAP); the difference was not statistically significant.
Our results show that increased ADMA, SDMA, and L-arginine concentrations are associated with increased PAP measurements in patients with COPD, however, the relationship is not statistically significant.
不对称二甲基精氨酸（ADMA）已成为许多与肺动脉高压（PH）相关病症的风险标志物；然而，关于慢性阻塞性肺疾病（COPD）中ADMA和对称二甲基精氨酸（SDMA）的血浆浓度知之甚少。我们的研究重点是ADMA在COPD和继发性PH中内皮功能调节中的作用。本研究的目的是评估COPD患者血清中ADMA、SDMA和L-精氨酸的浓度及其与PH的关联。
诊断为COPD的患者接受了肺功能测试、超声心动图检查以及包括ADMA、SDMA和L-精氨酸在内的实验室检查。
随着COPD病情进展，血清中ADMA、SDMA和L-精氨酸的浓度有升高趋势。与肺动脉压（PAP）正常的患者相比，PH患者的ADMA、SDMA和L-精氨酸浓度更高；但差异无统计学意义。
我们的结果表明，COPD患者中ADMA、SDMA和L-精氨酸浓度升高与PAP测量值增加相关，然而，这种关系无统计学意义。
