Perloy Andy, Schouten Leo J, van den Brandt Piet A, Godschalk Roger, van Schooten Frederik-Jan, Hogervorst Janneke G F
a Department of Epidemiology , GROW - School for Oncology and Developmental Biology, Maastricht University , Maastricht , The Netherlands.
b Department of Pharmacology and Toxicology , NUTRIM - School for Nutrition and Translational Research in Metabolism, Maastricht University , Maastricht , The Netherlands.
Nutr Cancer. 2018 May-Jun;70(4):620-631. doi: 10.1080/01635581.2018.1460682. Epub 2018 Apr 26.
To investigate the association between dietary acrylanide and advanced prostate cancer, we examined acrylamide-gene interactions for advanced prostate cancer risk by using data from the Netherlands Cohort Study. Participants (n = 58,279 men) completed a baseline food frequency questionnaire (FFQ), from which daily acrylamide intake was calculated. At baseline, 2,411 men were randomly selected from the full cohort for case-cohort analysis. Fifty eight selected single nucleotide polymorphisms (SNPs) and two gene deletions in genes in acrylamide metabolism, DNA repair, sex steroid systems, and oxidative stress were analyzed. After 20.3 years of follow-up, 1,608 male subcohort members and 948 advanced prostate cancer cases were available for Cox analysis. Three SNPs showed a main association with advanced prostate cancer risk after multiple testing correction: catalase (CAT) rs511895, prostaglandin-endoperoxide synthase 2 (PTGS2) rs5275, and xeroderma pigmentosum group C (XPC) rs2228001. With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk. After multiple testing corrections, none were statistically significant. In conclusion, no clear evidence was found for interaction between acrylamide intake and selected genetic variants for advanced prostate cancer risk.
为了研究膳食丙烯酰胺与晚期前列腺癌之间的关联，我们利用荷兰队列研究的数据，对晚期前列腺癌风险的丙烯酰胺-基因相互作用进行了研究。参与者（n = 58279名男性）完成了一份基线食物频率问卷（FFQ），并据此计算每日丙烯酰胺摄入量。在基线时，从整个队列中随机选取2411名男性进行病例-队列分析。对丙烯酰胺代谢、DNA修复、性类固醇系统和氧化应激相关基因中的58个单核苷酸多态性（SNP）和两个基因缺失进行了分析。经过20.3年的随访，1608名男性亚队列成员和948例晚期前列腺癌病例可用于Cox分析。经过多重检验校正后，三个SNP与晚期前列腺癌风险存在主要关联：过氧化氢酶（CAT）rs511895、前列腺素内过氧化物合酶2（PTGS2）rs5275和着色性干皮病C组（XPC）rs2228001。关于丙烯酰胺-基因相互作用，仅烟酰胺腺嘌呤二核苷酸磷酸（NAD(P)H）醌脱氢酶1（NQO1）中的rs1800566和硫氧还蛋白（TXN）中的rs2301241与丙烯酰胺摄入量在晚期前列腺癌风险方面显示出名义上具有统计学意义的相乘相互作用。经过多重检验校正后，均无统计学意义。总之，未发现丙烯酰胺摄入量与所选基因变异在晚期前列腺癌风险方面存在相互作用的明确证据。
