单纯疱疹病毒性上皮角膜炎的处理。
Management of herpes simplex virus epithelial keratitis.
机构信息
Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
出版信息
Curr Opin Ophthalmol. 2018 Jul;29(4):360-364. doi: 10.1097/ICU.0000000000000483.
PURPOSE OF REVIEW
To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis.
RECENT FINDINGS
Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Resistance to ACV has become a concerning issue. The animal models of HSV vaccine are able to reduce HSV keratitis. New antivirals are under development.
SUMMARY
Current cases of HSV epithelial keratitis are manageable with available medications, but new advancements are required to decrease disease burden in the future. HSV vaccine can be revolutionary.
目的综述
回顾单纯疱疹病毒（HSV）上皮性角膜炎治疗的最新进展。
最近发现
三氟胸苷眼药水、阿昔洛韦（ACV）眼膏、更昔洛韦凝胶和口服 ACV 仍是主要的治疗药物。最近已将冷冻羊膜用作辅助治疗。对 ACV 的耐药性已成为一个令人关注的问题。HSV 疫苗的动物模型能够减少 HSV 角膜炎。正在开发新的抗病毒药物。
总结
目前可通过现有药物治疗 HSV 上皮性角膜炎，但需要新的进展来减轻未来的疾病负担。HSV 疫苗具有革命性意义。
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