Polozova E I
Ogarev Mordovia State University, Saransk, Russia.
Khirurgiia (Mosk). 2018(4):71-76. doi: 10.17116/hirurgia2018471-76.
The purpose of this study was to efficacy of mexidol in the prevention of toxic damage to the heart in acute pancreatitis.
The paper presents the results of experimental studies conducted on 30 adult mongrel adult dogs, which simulated acute focal pancreatic necrosis. We studied the influence of mexidol in the complex therapy for changes in the qualitative and quantitative composition of the lipid tissue structures of the heart, the intensity of processes of lipid peroxidation, antioxidant capacity, phospholipase A activity and morphofunctional state of the heart muscle in experimental acute focal pancreatic necrosis. Th.
The preventive use of antioxidant drug mexidol in complex treatment of acute focal pancreatic necrosis, which limits the development of endogenous intoxication, increased intensity of lipid peroxidation and restores antioxidant capacity, reduces leading to phospholipase activity in tissue structures of the heart, corrigiruet lipid metabolism and morphofunctional state of the heart, and, consequently, toxic damage to the heart during endotoxic.
本研究的目的是探讨美西多宁在预防急性胰腺炎时心脏毒性损伤方面的疗效。
本文呈现了对30只成年杂种犬进行的实验研究结果，这些实验模拟了急性局灶性胰腺坏死。我们研究了美西多宁在综合治疗中对实验性急性局灶性胰腺坏死时心脏脂质组织结构的定性和定量组成变化、脂质过氧化过程强度、抗氧化能力、磷脂酶A活性以及心肌形态功能状态的影响。
在急性局灶性胰腺坏死的综合治疗中预防性使用抗氧化药物美西多宁，可限制内源性中毒的发展，增加脂质过氧化强度并恢复抗氧化能力，降低心脏组织结构中的磷脂酶活性，纠正心脏的脂质代谢和形态功能状态，从而减轻内毒素血症期间心脏的毒性损伤。
