Vlasov A P, Trofimov V A, Berezin V A, Tarasova T V, Ashirov R R, Saushev I V, Dubovskaia T N
Department of Surgery, Mordvinian State University, Bol'shevistskaya Str., 68, Saransk, 430000 Russia.
Eksp Klin Farmakol. 2003 Jan-Feb;66(1):40-5.
The chronic experiments on mongrel dogs with a model pancreatitis showed that mexidol decreases manifestations of the inflammatory process. The treatment with mexidol led to a decrease in the degree of lipid transformations in the initial stage of pancreatitis development, with normaliation of the lipid metabolism according to the liver and blood plasma characteristics. The membranoprotector effect of mexidol, manifested in normalization of the lipid spectrum, is probably related to inhibition of the lipid peroxidation (LPO) process and to a decrease in the activity of phospholipase A2. The correlation between lipid metabolism, LPO, and phospholipase A2 activity in the tissues studied indicates that the therapeutic effect of mexidol in animals with pancreatitis is based on the cytoprotector activity of the drug.
对患有模型胰腺炎的杂种狗进行的慢性实验表明，美西律可减轻炎症过程的表现。用美西律治疗可使胰腺炎发展初期脂质转化程度降低，并根据肝脏和血浆特征使脂质代谢恢复正常。美西律的膜保护作用表现为脂质谱正常化，这可能与抑制脂质过氧化（LPO）过程以及磷脂酶A2活性降低有关。所研究组织中脂质代谢、LPO和磷脂酶A2活性之间的相关性表明，美西律对胰腺炎动物的治疗作用基于该药物的细胞保护活性。
