Yoshikai Y, Matsuzaki G, Takeda Y, Ohga S, Kishihara K, Yuuki H, Nomoto K
Department of Immunology, Kyushu University, Fukuoka, Japan.
Eur J Immunol. 1988 Jul;18(7):1039-43. doi: 10.1002/eji.1830180711.
The rearrangement and expression of T cell antigen receptor (TcR) delta chain genes were investigated in congenitally athymic nude mice. The lymphoid cells derived from nude mice showed evidence of rearranged delta chain genes and a relatively high level of delta chain gene messages. Nucleotide sequence analysis revealed that nude mice contained an in-frame delta chain transcript, composed of V delta 5-D delta 1-D delta 2-J delta 1-C delta genes in the spleen. We have previously described functionally rearranged TcR gamma chain genes in the spleen of nude mice. Taken together, T cell precursors appear to proliferate and differentiate along the extrathymic pathway into TcR gamma/delta-bearing T cells in nude mice.
在先天性无胸腺裸鼠中研究了T细胞抗原受体（TcR）δ链基因的重排和表达。来自裸鼠的淋巴细胞显示出δ链基因重排的证据以及相对高水平的δ链基因信息。核苷酸序列分析表明，裸鼠脾脏中含有由Vδ5-Dδ1-Dδ2-Jδ1-Cδ基因组成的框内δ链转录本。我们之前曾描述过裸鼠脾脏中功能重排的TcRγ链基因。综上所述，T细胞前体似乎在裸鼠中沿着胸腺外途径增殖并分化为携带TcRγ/δ的T细胞。
