人类妊娠时胎盘后血液淋巴细胞对胎儿淋巴细胞增殖反应的抑制

Depression of proliferative response to fetal lymphocytes of retroplacental blood lymphocytes in human pregnancy.

作者信息

Yoshida M, Kanzaki H, Tokushige M, Sato S, Wang H S, Kariya M, Uchida A, Kasakura S, Mori T

机构信息

Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.

出版信息

Immunol Lett. 1988 Jun;18(2):155-8. doi: 10.1016/0165-2478(88)90057-0.

DOI:10.1016/0165-2478(88)90057-0

PMID:2969866

Abstract

Retroplacental blood lymphocytes (RPL) in human pregnancy were studied for proliferative response to related fetal lymphocytes and it was compared with that of peripheral blood lymphocytes (PBL) of the same donor. RPL proliferated poorly to related cord blood lymphocytes in 9 of 10 cases when compared with autologous PBL. RPL also showed lower proliferative response to unrelated adult lymphocytes in 7 of 12 cases. Proliferation of RPL was weaker to related cord blood lymphocytes than to allogeneic adult lymphocytes. These results indicate that the response of T cells at feto-maternal interface is impaired, especially to fetal antigens.

摘要

对人类妊娠时胎盘后血淋巴细胞（RPL）针对相关胎儿淋巴细胞的增殖反应进行了研究，并将其与同一供体的外周血淋巴细胞（PBL）的增殖反应进行比较。与自体PBL相比，10例中有9例RPL对相关脐血淋巴细胞的增殖反应较差。12例中有7例RPL对不相关成人淋巴细胞的增殖反应也较低。RPL对相关脐血淋巴细胞的增殖反应比对同种异体成人淋巴细胞的增殖反应弱。这些结果表明，胎儿-母体界面处T细胞的反应受损，尤其是对胎儿抗原的反应。