骨形态发生蛋白在人类卵巢中的作用。
The function of bone morphogenetic proteins in the human ovary.
作者信息
Yoshino Osamu, Shi Jia, Osuga Yutaka, Harada Miyuki, Nishii Osamu, Yano Tetsu, Taketani Yuji
机构信息
Department of Obstetrics and Gynecology University of Tokyo 7-3-1 Hongo, Bunkyo-ku 113-8655 Tokyo Japan.
Department of Obstetrics and Gynecology, Mizonokuchi Hospital Teikyo University 213-8507 Kawasaki Japan.
出版信息
Reprod Med Biol. 2011 Jan 6;10(1):1-7. doi: 10.1007/s12522-010-0072-3. eCollection 2011 Mar.
The gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH), are of particular importance in ovarian physiology. However, FSH receptors and LH receptors are not expressed until the secondary follicle stage, indicating that initiation of follicular growth is independent of the gonadotropins. Among many intra-ovarian growth factors, many studies have shown that bone morphogenetic proteins (BMPs) play pivotal roles in regulating the early phases of follicular growth. The BMP system induces the gonadotropin system by modulating gonadotropin receptors in early-stage follicles. Interestingly, the BMP system also prevents precocious maturation of the follicle by suppressing luteinization. Signals provoked by the preovulatory LH surge eliminate BMPs, enabling luteinization to progress. Thus, the BMP system and the gonadotropin system seem to cooperate in regulating follicular development, maturation, and luteinization.
促性腺激素，即卵泡刺激素（FSH）和黄体生成素（LH），在卵巢生理学中具有特别重要的意义。然而，FSH受体和LH受体直到次级卵泡阶段才表达，这表明卵泡生长的启动独立于促性腺激素。在众多卵巢内生长因子中，许多研究表明骨形态发生蛋白（BMPs）在调节卵泡生长的早期阶段发挥着关键作用。BMP系统通过调节早期卵泡中的促性腺激素受体来诱导促性腺激素系统。有趣的是，BMP系统还通过抑制黄体化来防止卵泡过早成熟。排卵前LH峰引发的信号消除了BMPs，使黄体化得以进行。因此，BMP系统和促性腺激素系统似乎在协同调节卵泡的发育、成熟和黄体化。
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