男性不育症的干细胞研究。
Stem cell research for male infertility.
作者信息
Kobayashi Hideyuki, Nagao Koichi, Nakajima Koichi
机构信息
Department of Urology Toho University School of Medicine 6-11-1 Omori-Nishi, Ota-ku 143-8541 Tokyo Japan.
出版信息
Reprod Med Biol. 2011 Apr 26;10(3):171-174. doi: 10.1007/s12522-011-0085-6. eCollection 2011 Sep.
Stem cells have the ability both to differentiate into numerous tissues and to self-renew. Because of these unique properties, stem cells are promising candidates for use in regenerative medicine. Among stem cell types, embryonic stem (ES) cells have been the most studied; however, alternatives such as induced pluripotent stem cells or other adult stem cells are now being established. In this review, we focus on stem cell research that may have applications in treating male infertility. Stem cells with ES-like properties have been generated from adult human testis tissue. We expect that breakthroughs in stem cell research will increase our understanding of male infertility and lead to treatments in the near future.
干细胞具有分化为多种组织以及自我更新的能力。由于这些独特的特性，干细胞是再生医学中很有前景的候选者。在干细胞类型中，胚胎干细胞（ES细胞）受到的研究最多；然而，诸如诱导多能干细胞或其他成体干细胞等替代细胞类型目前正在建立。在这篇综述中，我们聚焦于可能在治疗男性不育症方面有应用的干细胞研究。具有类ES细胞特性的干细胞已从成年人类睾丸组织中产生。我们期望干细胞研究的突破将增进我们对男性不育症的理解，并在不久的将来带来治疗方法。
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