Bai Hanako, Sakurai Toshihiro, Fujiwara Hiroshi, Ideta Atsushi, Aoyagi Yoshito, Godkin James D, Imakawa Kazuhiko
Laboratory of Animal Breeding and Reproduction, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences The University of Tokyo 1-1-1 Yayoi, Bunkyo-ku 113-8657 Tokyo Japan.
Department of Gynecology and Obstetrics, Faculty of Medicine Kyoto University Sakyo-ku 606-8397 Kyoto Japan.
Reprod Med Biol. 2012 Jan 25;11(3):109-116. doi: 10.1007/s12522-011-0117-2. eCollection 2012 Jul.
The establishment of a successful pregnancy requires a "fine quality embryo", "maternal recognition of pregnancy", and a "receptive uterus" during the period of conceptus implantation to the uterine endometrium. In ruminants, a conceptus cytokine, interferon tau (IFNT), a major cytokine produced by the peri-implantation trophectoderm, is known as a key factor for maternal recognition of pregnancy. IFNT can be considered one of the main factors in conceptus-uterus cross-talk, resulting in the rescue of ovarian corpus luteum (CL), induction of endometrial gene expressions, activation of residual immune cells, and recruitment of immune cells. Much research on IFNT has focused on the CL life-span (pregnancy recognition) and uterine gene expression through IFNT and related genes; however, immunological acceptance of the conceptus by the mother has not been well characterized. In this review, we will discuss the progress in IFNT and implantation research made by us and others for over 10 years, and relate this progress to pregnancy in mammalian species other than ruminants.
成功妊娠的建立需要在孕体植入子宫内膜期间具备“优质胚胎”、“母体对妊娠的识别”以及“容受性子宫”。在反刍动物中，孕体细胞因子——干扰素 tau（IFNT），一种由植入前期滋养外胚层产生的主要细胞因子，被认为是母体识别妊娠的关键因素。IFNT 可被视为孕体与子宫相互作用的主要因素之一，它能维持卵巢黄体（CL）功能、诱导子宫内膜基因表达、激活残留免疫细胞并募集免疫细胞。关于 IFNT 的许多研究都集中在 CL 的寿命（妊娠识别）以及通过 IFNT 和相关基因调控子宫基因表达方面；然而，母体对孕体的免疫接受情况尚未得到充分表征。在这篇综述中，我们将讨论我们和其他研究人员在过去 10 多年里在 IFNT 和植入研究方面取得的进展，并将这一进展与反刍动物以外的其他哺乳动物物种的妊娠联系起来。
