Fujiwara Hiroshi, Sato Yukiyasu, Nishioka Yoshihiro, Yoshioka Shinya, Kosaka Kenzo, Fujii Haruko, Tatsumi Keiji, Egawa Miho, Zeng Bin-Xiang, Furukawa Kazumi, Higuchi Toshihiro
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Kyoto, Japan.
Reprod Med Biol. 2005 Jul 28;4(3):189-195. doi: 10.1111/j.1447-0578.2005.00104.x. eCollection 2005 Sep.
Human extravillous trophoblasts (EVT) invade maternal deciduas and reconstructed maternal spiral arteries during early placentation. However, the precise regulatory mechanisms to induce EVT invasion toward arteries and/or to protect EVT from further invasion have not been well understood. Recently, it was found that EVT that had already ceased their invasion, specifically expressed cluster of differentiation (CD9) and dipeptidyl peptidase IV (DPPIV) on their cell surface. In addition, EVT migrating to maternal spiral arteries expressed CC chemokine receptor type-1 (CCR-1), which is a chemokine receptor for regulated on activation normal T cell expressed and secreted (RANTES) and so on. CD9 is associated with integrin molecules on the cell surface and is considered to modulate integrin function. In contrast, DPPIV is a cell surface peptidase that can metabolize RANTES at extracellular sites before its accessing to the chemokine receptors. functional assay showed that CD9, DPPIV and RANTES are involved in the regulation for EVT invasion. From these findings, it can be proposed that CD9 and DPPIV, including chemokines, are new regulatory factors for human extravillous trophoblasts. (Reprod Med Biol 2005; : 189-195).
人绒毛外滋养层细胞（EVT）在胎盘形成早期侵入母体蜕膜并重建母体螺旋动脉。然而，诱导EVT向动脉侵袭和/或保护EVT避免进一步侵袭的精确调控机制尚未完全明确。最近发现，已经停止侵袭的EVT在其细胞表面特异性表达分化簇（CD9）和二肽基肽酶IV（DPPIV）。此外，迁移至母体螺旋动脉的EVT表达CC趋化因子受体1型（CCR-1），它是一种受激活调节的正常T细胞表达和分泌因子（RANTES）等的趋化因子受体。CD9与细胞表面的整合素分子相关，被认为可调节整合素功能。相反，DPPIV是一种细胞表面肽酶，可在RANTES进入趋化因子受体之前在细胞外位点将其代谢。功能分析表明，CD9、DPPIV和RANTES参与了对EVT侵袭的调控。基于这些发现，可以提出包括趋化因子在内的CD9和DPPIV是人类绒毛外滋养层细胞新的调控因子。（《生殖医学与生物学》2005年；：189 - 195）
