Zhang Sainan, Ding Jinli, Zhang Yan, Liu Su, Yang Jing, Yin Tailang
Reproductive Medical Center, Renmin Hospital of Wuhan University & Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Front Cell Dev Biol. 2022 Jul 22;10:826053. doi: 10.3389/fcell.2022.826053. eCollection 2022.
Successful pregnancy requires the maternal immune system to tolerate the semi-allogeneic embryo. A good trophoblast function is also essential for successful embryo implantation and subsequent placental development. Chemokines are initially described in recruiting leukocytes. There are rich chemokines and chemokine receptor system at the maternal-fetal interface. Numerous studies have reported that they not only regulate trophoblast biological behaviors but also participate in the decidual immune response. At the same time, the chemokine system builds an important communication network between fetally derived trophoblast cells and maternally derived decidual cells. However, abnormal functions of chemokines or chemokine receptors are involved in a series of pregnancy complications. As growing evidence points to the roles of chemokines in pregnancy, there is a great need to summarize the available data on this topic. This review aimed to describe the recent research progress on the regulation and function of the main chemokines in pregnancy at the maternal-fetal interface. In addition, we also discussed the potential relationship between chemokines and pregnancy complications.
成功妊娠需要母体免疫系统耐受半同种异体胚胎。良好的滋养层功能对于胚胎成功着床及随后的胎盘发育也至关重要。趋化因子最初被描述为在募集白细胞方面发挥作用。母胎界面存在丰富的趋化因子和趋化因子受体系统。众多研究报道，它们不仅调节滋养层生物学行为，还参与蜕膜免疫反应。同时，趋化因子系统在胎儿来源的滋养层细胞和母体来源的蜕膜细胞之间构建了一个重要的通讯网络。然而，趋化因子或趋化因子受体的功能异常与一系列妊娠并发症有关。随着越来越多的证据表明趋化因子在妊娠中的作用，非常有必要总结关于这一主题的现有数据。本综述旨在描述母胎界面主要趋化因子在妊娠中的调节和功能方面的最新研究进展。此外，我们还讨论了趋化因子与妊娠并发症之间的潜在关系。
