Okamoto Machi, Sakakibara Hideya, Yoshida Hiroshi, Fukazawa Yuka, Takashima Kunitomo, Kondo Yoshihito, Ikeda Mario, Ishikawa Masahiko, Hirahara Fumiki
Department of Gynecology Yokohama City University, Medical Center 4-57 Urafune-cho, Minami 232-0024 Yokohama Kanagawa Japan.
Department of Obstetrics and Gynecology Yokohama City University, School of Medicine 3-9 Fukuura, Kanazawa 236-0004 Yokohama Kanagawa Japan.
Reprod Med Biol. 2010 Jun 22;9(4):191-195. doi: 10.1007/s12522-010-0057-2. eCollection 2010 Dec.
It is sometimes difficult to restore a regular ovulatory cycle in women with polycystic ovary syndrome (PCOS) using classic agents such as clomiphene citrate or gonadotropins. Saireito, a herbal medicine, is believed to have an effect similar to corticosteroids. We examined the effect of Saireito on ovulatory induction and endocrine status in women with PCOS.
Twenty-four women with PCOS were treated with Saireito for 3 months. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone (T), estradiol (E), adrenocorticotropic hormone (ACTH), and cortisol were measured before and after treatment, and ovulation was assessed. We compared serum LH levels between ovulation ( = 21) and anovulation ( = 3) groups, and compared ovulation rate and serum LH levels between obese ( = 6) and nonobese ( = 18) groups.
Ovulation was restored in 21 (87.5%) of the 24 PCOS patients following administration of Saireito for 3 months. LH levels were significantly decreased 1 month after medication in ovulatory group ( < 0.001), but only slightly decreased in anovulatory group. Ovulation rate in the nonobese group (94.4%) was higher than in the obese group (66.7%). Serum LH levels were significantly reduced in the nonobese group, but only slightly reduced in the obese group.
Saireito reduced serum LH levels and increased ovulatory rate, particularly in nonobese women.
对于多囊卵巢综合征（PCOS）女性，使用克罗米芬柠檬酸盐或促性腺激素等传统药物有时难以恢复规律的排卵周期。柴苓汤是一种草药，被认为具有与皮质类固醇类似的作用。我们研究了柴苓汤对PCOS女性排卵诱导及内分泌状态的影响。
24例PCOS女性接受柴苓汤治疗3个月。在治疗前后测量血清促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）、睾酮（T）、雌二醇（E）、促肾上腺皮质激素（ACTH）和皮质醇，并评估排卵情况。我们比较了排卵组（n = 21）和无排卵组（n = 3）之间的血清LH水平，以及肥胖组（n = 6）和非肥胖组（n = 18）之间的排卵率和血清LH水平。
24例PCOS患者在服用柴苓汤3个月后，21例（87.5%）恢复排卵。排卵组用药1个月后LH水平显著降低（P < 0.001），而无排卵组仅略有降低。非肥胖组的排卵率（94.4%）高于肥胖组（66.7%）。非肥胖组血清LH水平显著降低，而肥胖组仅略有降低。
柴苓汤降低了血清LH水平并提高了排卵率，尤其是在非肥胖女性中。
