Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Kaohsiung J Med Sci. 2018 May;34(5):274-280. doi: 10.1016/j.kjms.2017.12.010. Epub 2018 Jan 20.
Type 1 diabetes is a multi-factorial disease that can develop due to the combination of genetic and environmental factors. Viruses, particularly enteroviruses, are major environmental candidates in the pathogenesis of type 1 diabetes, even though the mechanisms of pathogenicity of these viruses and their effects on the immune system have not been understood very well yet. Previous studies show that any imbalance in the population of different lymphocyte subsets could develop autoimmune diseases. Our theory is that enteroviral infection causes an impairment in the distribution of lymphocyte subtypes and consequently results in the diabetes onset in some individuals. Therefore, in this project, we evaluated the distribution of T CD8+ lymphocytes and their subsets in type 1 diabetes patients. This study was conducted to investigate the relationship between enteroviral infection and type 1 diabetes mellitus in an Iranian population, and suggestion a predicting approach for susceptible subjects.
1 型糖尿病是一种多因素疾病，可能由于遗传和环境因素的共同作用而发生。病毒，特别是肠道病毒，是 1 型糖尿病发病机制中的主要环境候选因素，尽管这些病毒的发病机制及其对免疫系统的影响尚未得到很好的理解。先前的研究表明，不同淋巴细胞亚群的数量失衡可能会导致自身免疫性疾病的发生。我们的理论是，肠道病毒感染导致淋巴细胞亚群分布异常，从而导致某些个体发生糖尿病。因此，在本项目中，我们评估了 1 型糖尿病患者 T CD8+淋巴细胞及其亚群的分布。本研究旨在探讨肠道病毒感染与伊朗人群中 1 型糖尿病的关系，并提出一种针对易感人群的预测方法。
