Tham Tristan, Bardash Yonatan, Teegala Sushma, Herman Wendy Saori, Costantino Peter David
Department of Otolaryngology - Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA.
Department of Otolaryngology - Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA.
Am J Otolaryngol. 2018 Jul-Aug;39(4):453-458. doi: 10.1016/j.amjoto.2018.04.013. Epub 2018 Apr 21.
The aim of this systematic review and meta-analysis was to investigate the relationship between the Red Cell Distribution Width (RDW) and prognosis in upper aerodigestive tract (UADT) cancer.
PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled hazard ratios (HR) for overall survival (OS), disease specific survival (DSS), and recurrence free survival (RFS).
Our analysis included the results of 4200 patients in 8 cohorts. The pooled data demonstrated that an elevated RDW was associated with significantly poorer OS (HR: 1.44, 95% CI: 1.13-1.83), RFS (HR: 1.43, 95%CI: 1.13-1.82). The DSS result had high heterogeneity and 95% CI was not pooled.
An elevated RDW may be an indicator of poor prognosis in UADT cancers in certain populations. Further research is needed to confirm this effect.
本系统评价和荟萃分析旨在研究红细胞分布宽度（RDW）与上消化道（UADT）癌预后之间的关系。
检索了PubMed（通过网络）、Embase、Scopus和Cochrane图书馆。进行了系统评价和荟萃分析，以生成总生存期（OS）、疾病特异性生存期（DSS）和无复发生存期（RFS）的合并风险比（HR）。
我们的分析纳入了8个队列中4200例患者的结果。汇总数据表明，RDW升高与OS显著较差（HR：1.44，95%CI：1.13-1.83）、RFS（HR：1.43，95%CI：1.13-1.82）相关。DSS结果具有高度异质性，未汇总95%CI。
RDW升高可能是特定人群UADT癌预后不良的一个指标。需要进一步研究来证实这种效应。
