Rottembourg J, Brouard R, Issad B, Allouache M, Nguyen J, Montassine M C, Kirstein E, Jacobs C
Service de Néphrologie, Groupe Hospitalier Pitié-Salpêtrière.
Presse Med. 1988 Jul 2;17(26):1349-53.
Peritonitis remains the major obstacle to the acceptance of continuous ambulatory peritoneal dialysis as a long-term dialysis technique. In January, 1985, Y connectors were introduced into our continuous ambulatory peritoneal dialysis programme, and a two-year prospective randomized trial for all new patients was initiated in which the Y connection system was compared with the conventional technique in the prevention of peritonitis (group I). At the same time, 16 patients (group II), with a high incidence of peritonitis episodes were switched from the conventional technique to the Y connection system, while 55 patients (group III), remained on the conventional technique. Group IA patients (27 new patients using the Y connection system), developed peritonitis every 23 patient-months. Group IB patients (28 new patients using the conventional technique), developed peritonitis every 12.2 patient-months. The difference between these two sub-groups was statistically significant (P less than 0.02). Before their transfer to the Y connection system, group II patients developed peritonitis every 10 patient-months and thereafter one every 24 patient-months (P less than 0.001). Group III patients were divided into 12 continuous cyclic peritoneal dialysis patients with peritonitis every 24 patients-months, and 43 continuous ambulatory peritoneal dialysis patients with peritonitis every 11.7 patient-months. The Y connector therefore proved to be a simple and safe procedure effective in reducing the peritonitis rate in patients on continuous ambulatory peritoneal dialysis.
腹膜炎仍然是持续性非卧床腹膜透析作为一种长期透析技术被广泛接受的主要障碍。1985年1月,Y形连接器被引入我们的持续性非卧床腹膜透析项目,并对所有新患者启动了一项为期两年的前瞻性随机试验,在该试验中,将Y形连接系统与传统技术在预防腹膜炎方面进行比较(第一组)。同时,16例腹膜炎发作发生率高的患者(第二组)从传统技术转换为Y形连接系统,而55例患者(第三组)继续采用传统技术。第一组A患者(27例使用Y形连接系统的新患者)每23个患者月发生一次腹膜炎。第一组B患者(28例使用传统技术的新患者)每12.2个患者月发生一次腹膜炎。这两个亚组之间的差异具有统计学意义(P小于0.02)。在转用Y形连接系统之前,第二组患者每10个患者月发生一次腹膜炎,之后每24个患者月发生一次(P小于0.001)。第三组患者分为12例持续性循环腹膜透析患者,每24个患者月发生一次腹膜炎,以及43例持续性非卧床腹膜透析患者,每11.7个患者月发生一次腹膜炎。因此,Y形连接器被证明是一种简单安全的方法,可有效降低持续性非卧床腹膜透析患者的腹膜炎发生率。