Department of Internal Medicine, Adult Cystic Fibrosis Care Center, Hospices Civils de Lyon, Lyon, France.
EA HESPER 7425, Université Claude Bernard Lyon 1, Lyon, France.
Clin Transplant. 2018 Jun;32(6):e13269. doi: 10.1111/ctr.13269. Epub 2018 May 17.
Lung transplantation (LT) is the standard therapeutic option for cystic fibrosis (CF) patients with end-stage lung disease. Both conditions lead to extrarespiratory complications, such as diabetes, renal insufficiency, bone disease, and cancer. The purpose of this study was to provide an update of the nonrespiratory comorbidities following LT in adult patients with CF and their specificities regarding their multisystemic underlying condition despite their younger age compared to other patients undergoing LT. Diabetes, renal insufficiency, metabolic bone disease, hypertension, liver disease, and cancer are the comorbidities considered in this review. The increase in CF adults living with a lung transplant justifies an update of knowledge for this specific situation (the prevalence of these complications, underlying risk factors), to provide better medical care and establish early diagnosis strategies.
肺移植（LT）是终末期肺部疾病的囊性纤维化（CF）患者的标准治疗选择。这两种疾病都会导致呼吸以外的并发症，如糖尿病、肾功能不全、骨病和癌症。本研究的目的是提供 CF 成人 LT 后非呼吸性合并症的最新信息，以及与其他接受 LT 的患者相比，尽管他们年龄较小，但由于其多系统基础疾病的特殊性。本综述考虑了糖尿病、肾功能不全、代谢性骨病、高血压、肝病和癌症等合并症。随着 CF 成人与肺移植一起生活的人数增加， justifies an update of knowledge for this specific situation（这些并发症的患病率、潜在风险因素），以提供更好的医疗护理并建立早期诊断策略。
