Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
School of Psychology, Fairleigh Dickinson University, Teaneck, NJ, USA.
Eur Eat Disord Rev. 2018 Sep;26(5):489-498. doi: 10.1002/erv.2597. Epub 2018 Apr 27.
A neurocognitive profile characterized by problems in set shifting, executive functioning, and central coherence may pre-date and maintain anorexia nervosa (AN). To test this pattern as a possible endophenotype for AN, 10 youth with current AN, 14 healthy youth, and their biological parents, participated in a neuropsychological battery. Youth with AN demonstrated significantly weaker central coherence, related to enhanced detail-focused processing. Youth with AN and their parents demonstrated significantly greater psychopathology relative to controls, and youth-parent scores were significantly correlated. The study, limited by a small sample size, found little evidence supporting a neuropsychological endophenotype for AN. Identifying a neurocognitive profile for children and adolescents with AN has important implications for the treatment of young patients.
一个以转换能力、执行功能和中枢连贯问题为特征的神经认知特征可能先于并维持神经性厌食症 (AN)。为了检验这一模式是否为 AN 的可能内表型，10 名患有当前 AN 的年轻人、14 名健康的年轻人及其亲生父母参加了一项神经心理学测试。患有 AN 的年轻人表现出明显较弱的中枢连贯，这与增强的细节聚焦处理有关。与对照组相比，患有 AN 的年轻人及其父母表现出明显更多的精神病理学症状，并且年轻人和父母的分数呈显著相关。这项研究因样本量小而受到限制，几乎没有证据支持 AN 的神经心理学内表型。确定患有 AN 的儿童和青少年的神经认知特征对年轻患者的治疗具有重要意义。
