Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, People's Republic of China.
Hainan Academy of Ocean and Fisheries Sciences, Haikou 570203, People's Republic of China.
Fitoterapia. 2018 Jun;127:25-28. doi: 10.1016/j.fitote.2018.03.008. Epub 2018 Apr 25.
An unusual benzoisoindole-deferoxamine hybrid, streptoxamine (1), has been isolated from the ethyl acetate crude extract of the fermentation broth of a locust-associated actinomycete, Streptomyces sp. HKHCa2, which was isolated from an insect, Oxya chinensis. The structure of this secondary metabolite was elucidated on the basis of its one-dimension, two-dimension NMR, and mass spectroscopic data. This natural product features a hybrid pattern of a benzoisoindole with an "iron carrier" deferoxamine B through C-N linkage. Compound 1 showed weak antibacterial activity against the gram-positive bacteria, Staphylococcus aureus and Mycobacterium smegmatis.
从一种与蝗虫有关的放线菌——链霉菌属 HKHCa2 的发酵液的乙酸乙酯粗提物中分离到一种罕见的苯并异吲哚-去铁胺杂合体，链霉胍（1）。这种次生代谢产物的结构是根据其一维、二维 NMR 和质谱数据确定的。这种天然产物的特征是通过 C-N 键连接苯并异吲哚和“铁载体”去铁胺 B 的杂合模式。化合物 1 对革兰氏阳性菌金黄色葡萄球菌和耻垢分枝杆菌表现出较弱的抗菌活性。
