Gagnon R M, Morissette M, Laramée P, Dumont G, Sestier F, Leclerc G, Goudreau E
Department of Medicine, University of Montreal, Notre-Dame Hospital.
CMAJ. 1988 Sep 1;139(5):405-8.
Between June 1984 and December 1986, 35 patients with acute myocardial infarction received streptokinase intravenously within 3 hours after the beginning of chest pain and underwent percutaneous transluminal coronary angioplasty (PTCA) either immediately (in 2 cases) or 1 to 19 (mean 4.4) days later (in 33). The rate of successful PTCA was 89%. Reocclusion occurred in one patient. The mean percentage of stenosis decreased from 86% to 11%. The mean trans-stenotic gradient was reduced from 41 to 11 mm Hg. The results suggest that in patients whose condition is stable, PTCA performed a few days after thrombolysis is a valuable alternative to more aggressive treatment with immediate PTCA.
1984年6月至1986年12月期间，35例急性心肌梗死患者在胸痛发作后3小时内静脉注射链激酶，并于胸痛发作后即刻（2例）或1至19天（平均4.4天）后（33例）接受经皮腔内冠状动脉成形术（PTCA）。PTCA成功率为89%。1例患者发生再闭塞。狭窄平均百分比从86%降至11%。平均跨狭窄压差从41 mmHg降至11 mmHg。结果表明，对于病情稳定的患者，溶栓治疗几天后进行PTCA是比立即进行PTCA等更积极治疗更有价值的替代方案。
