2D:4D 比率与神经发育障碍：一项双胞胎研究。
2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study.
机构信息
Division of Neuropsychiatry, Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet & Center for Psychiatry Research, Stockholm County Council, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Autism Dev Disord. 2018 Sep;48(9):3244-3252. doi: 10.1007/s10803-018-3588-8.
The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs.
2D:4D 比值在自闭症谱系障碍（ASD）中受到关注。然而，目前关于该比值与其他神经发育障碍（NDD）之间关系的研究还很缺乏。在双胞胎中研究比值与 NDD 之间的关系可以深入了解导致比值变化的遗传和/或环境因素。本研究共纳入了 238 名患有 NDD 或典型发育的双胞胎，采集了他们的手部图像，来自 70 对同卵双胞胎和 49 对异卵双胞胎，以检查比值与 DSM-5 定义的 NDD 类别、自闭症特征、同卵性和性别之间的关联。对于男性，比值与任何 NDD 和 ADHD 诊断之间都存在较小的关联。男性的比值低于女性。未来的研究可以进一步探索比值与身体异常之间的关系，为 NDD 的病因学提供深入的见解。
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