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中国大学生细胞色素 P450（CYP）基因单核苷酸多态性与第二至第四指长比的关联。

Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students.

机构信息

Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education/Key Laboratory of Reproduction and Genetics/Basic Medical College, Ningxia Medical University, Yinchuan, Ningxia, China (mainland).

Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, Ningxia, China (mainland).

出版信息

Med Sci Monit. 2021 Mar 16;27:e930591. doi: 10.12659/MSM.930591.

DOI:10.12659/MSM.930591
PMID:33723203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7980499/
Abstract

BACKGROUND Cytochrome P450 (CYP) genes are necessary for the production or metabolism of fetal sex hormones during pregnancy. The second-to-fourth digit ratio (2D: 4D) is formed in the early stage of human fetal development and considered an indicator reflecting prenatal sex steroids levels. We explored the association between 2D: 4D and single-nucleotide polymorphisms (SNPs) of CYP. MATERIAL AND METHODS Correlation analysis between 2D: 4D and 8 SNPs, rs2687133 (CPY3A7), rs7173655 (CYP11A1), rs1004467, rs17115149, and rs2486758 (CYP17A1), and rs4646, rs2255192, rs4275794 (CYP19A1), was performed using data from 426 female and 412 male Chinese university students. SNP genotyping was conducted using PCR. Digit lengths were photographed and measured by image processing software. RESULTS rs2486758 (CYP17A1) correlated with left hand 2D: 4D in men (P=0.026), and rs1004467 (CYP17A1) correlated with right hand 2D: 4D in men (P=0.008) and the whole population (P=0.032). In men, allele G rs1004467 decreased right hand 2D: 4D, while allele C of rs2486758 increased left hand 2D: 4D. In women, left hand 2D: 4D was higher in genotypes with allele A of SNP rs4646 (CYP19A1) under the dominant genetic model; female DR-L was higher in genotypes with allele T of rs17115149 (CYP11A1). SNPs rs2687133 (CYP3A7) and rs1004467 (CYP17A1) were significantly correlated with right hand 2D: 4D (P=0.0107). CONCLUSIONS SNPs rs1004467 and rs2486758 of CYP17A1 are significant in the relationship between 2D: 4D and CYP gene polymorphisms under different conditions. SNP interactions between CYP genes probably impact 2D: 4D. The correlation between 2D: 4D and some sex hormone-related diseases may be due to the effect of CYP variants on the 2 phenotypes.

摘要

背景

细胞色素 P450（CYP）基因对于妊娠期间胎儿性激素的产生或代谢是必要的。第二至第四指骨长度比（2D：4D）在人类胎儿发育的早期形成，被认为是反映产前性激素水平的指标。我们探讨了 2D：4D 与 CYP 的单核苷酸多态性（SNP）之间的关联。

材料和方法

使用 426 名女性和 412 名男性中国大学生的数据，对 2D：4D 与 8 个 SNP（rs2687133（CPY3A7）、rs7173655（CYP11A1）、rs1004467、rs17115149 和 rs2486758（CYP17A1）以及 rs4646、rs2255192 和 rs4275794（CYP19A1））之间的相关性进行了分析。使用 PCR 进行 SNP 基因分型。使用图像处理软件拍摄和测量指长。

结果

rs2486758（CYP17A1）与男性左手 2D：4D 相关（P=0.026），rs1004467（CYP17A1）与男性右手 2D：4D 相关（P=0.008）和全人群相关（P=0.032）。在男性中，SNP rs1004467 的等位基因 G 降低了右手 2D：4D，而 rs2486758 的等位基因 C 增加了左手 2D：4D。在女性中，SNP rs4646（CYP19A1）的显性遗传模型下，等位基因 A 的基因型左手 2D：4D 较高；rs17115149（CYP11A1）的等位基因 T 的女性 DR-L 较高。SNP rs2687133（CPY3A7）和 rs1004467（CYP17A1）与右手 2D：4D 显著相关（P=0.0107）。

结论

CYP17A1 的 rs1004467 和 rs2486758 在不同条件下 2D：4D 与 CYP 基因多态性之间的关系中具有显著意义。CYP 基因之间的 SNP 相互作用可能影响 2D：4D。2D：4D 与某些与性激素相关的疾病之间的相关性可能归因于 CYP 变体对 2 种表型的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/a21743b13173/medscimonit-27-e930591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/ded3ab6c1859/medscimonit-27-e930591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/4338d566c352/medscimonit-27-e930591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/a21743b13173/medscimonit-27-e930591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/ded3ab6c1859/medscimonit-27-e930591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/4338d566c352/medscimonit-27-e930591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bfb/7980499/a21743b13173/medscimonit-27-e930591-g003.jpg

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