Campetella O E, Barrios H A, Galassi N V
Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Immunology. 1988 Jul;64(3):407-12.
Intracerebral (i.c.) Junin virus (JV) infection of adult BALB/c mice is characterized by the absence of morbidity and a low mortality (barely 8-10%). In contrast, the suckling mouse model exhibits almost 100% mortality following central nervous system (CNS) alterations consistent with a delayed-type hypersensitivity (DTH)-like immune response. Besides, JV infection of adult (resistant) mice leads to immunosuppression of DTH to unrelated antigens. Here we present evidence demonstrating that such suppression is mediated by JV-induced cells present in spleen from 24 hr to 24 days post-infection, bearing the Thy-1+, Ly-1+2- phenotype and reactive to an unrelated antigen such as sheep red blood cells (SRBC). No evidence of suppressor factors was found. A relatively low number of total splenic cells (5 x 10(6) cells/mouse) was enough to transfer suppression. Therefore, this cell population may be involved in adult mouse survival to JV infection.
成年BALB/c小鼠脑内（i.c.）感染胡宁病毒（JV）的特征是无发病症状且死亡率低（仅8 - 10%）。相比之下，乳鼠模型在出现与迟发型超敏反应（DTH）样免疫反应一致的中枢神经系统（CNS）改变后，死亡率几乎为100%。此外，成年（抗性）小鼠感染JV会导致对无关抗原的DTH免疫抑制。在此，我们提供证据表明这种抑制是由感染后24小时至24天存在于脾脏中的JV诱导细胞介导的，这些细胞具有Thy-1 +、Ly-1 + 2 - 表型，且对诸如绵羊红细胞（SRBC）等无关抗原具有反应性。未发现抑制因子的证据。相对少量的脾细胞总数（5×10⁶个细胞/小鼠）就足以传递抑制作用。因此，这群细胞可能与成年小鼠对JV感染的存活有关。
