Nordic Bioscience A/S, Herlev, Denmark.
Nordic Bioscience A/S, Herlev, Denmark; Division of Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University, Lund, Sweden.
J Proteomics. 2019 Jan 6;190:55-66. doi: 10.1016/j.jprot.2018.04.030. Epub 2018 Apr 25.
Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. OA pain is multifactorial and may arise from multiple distinct or concurrent mechanisms, and may thus present as different pain sub-types. Several biomarkers developed to reflect important pathological processes are available, and associations between such biomarkers and OA pain may give hints to important pathological features, which have not been possible to assess using clinical, radiographic or magnetic resonance imaging techniques. This review highlights a selection of important, protein-derived biomarkers measured in body fluids from OA patients, which have been associated with different types and aspects of OA pain, and discusses the potential mechanisms behind the associations. SIGNIFICANCE: Osteoarthritis (OA) is a heterogenous disease affecting the entire joint, including cartilage, bone and synovium. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. Thus, there is clear need for biomarkers that can accurately describe the underlying processes and distinguish between different disease and pain pathologies. In this review we discuss a selected number of biomarkers which have been directly or indirectly associated with pain mechanisms and development of pain in OA either via structural correlates or as molecular sensitizing agents. We further evaluate the challenges that the OA field faces in the development and application of biomarkers for OA pain.
骨关节炎（OA）是世界上最常见的关节炎疾病，导致衰弱性疼痛和关节组织破坏。虽然疼痛是骨关节炎的标志症状，但疼痛与关节退化涉及的疾病过程之间缺乏明确的关联。OA 疼痛是多因素的，可能来自多个不同或同时发生的机制，因此可能表现为不同的疼痛亚型。已经开发出几种用于反映重要病理过程的生物标志物，这些生物标志物与 OA 疼痛之间的关联可能提示重要的病理特征，这些特征使用临床、放射学或磁共振成像技术是无法评估的。这篇综述重点介绍了从 OA 患者的体液中测量的一些重要的、源自蛋白质的生物标志物，这些生物标志物与 OA 疼痛的不同类型和方面有关，并讨论了关联背后的潜在机制。意义：骨关节炎（OA）是一种影响整个关节的异质性疾病，包括软骨、骨和滑膜。虽然疼痛是骨关节炎的标志症状，但疼痛与关节退化涉及的疾病过程之间缺乏明确的关联。因此，显然需要能够准确描述潜在过程并区分不同疾病和疼痛病理的生物标志物。在这篇综述中，我们讨论了一些生物标志物，这些标志物直接或间接地通过结构相关性或作为分子敏化剂与 OA 疼痛的机制和疼痛发展相关。我们进一步评估了 OA 领域在开发和应用 OA 疼痛生物标志物方面面临的挑战。
