Leyden J J
Duhring Laboratories, University of Pennsylvania, Philadelphia 19104.
J Am Acad Dermatol. 1988 Jul;19(1 Pt 2):164-8. doi: 10.1016/s0190-9622(88)70160-7.
Retinoids, chemicals that have vitamin A activity, have become important therapeutic agents for a variety of cutaneous disorders, including acne. This paper reviews the history of retinoid use in acne, including retinol, topical tretinoin, topical and systemic isotretinoin, systemic etretinate, and new investigational retinoid molecules.
维甲酸类物质，即具有维生素A活性的化学物质，已成为治疗包括痤疮在内的多种皮肤疾病的重要治疗药物。本文回顾了维甲酸类药物在痤疮治疗中的应用历史，包括视黄醇、外用维甲酸、外用和口服异维甲酸、口服阿维A酯以及新型研究中的维甲酸类分子。
