Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Exp Dermatol. 2018 Aug;27(8):841-846. doi: 10.1111/exd.13674. Epub 2018 Jun 28.
The barrier function of skin is indispensable for terrestrial animals. This function is mainly carried out by the epidermis, more specifically by its granular and cornified layers. The major structural components associated with this function are the intercellular lipid layer, desmosomes, corneodesmosomes, tight junctions, cornified cell envelope and keratin filaments. In this review, we discuss the current knowledge of their ultrastructure, their molecular basis and their relevance to skin disease.
皮肤的屏障功能对于陆生动物来说是不可或缺的。该功能主要由表皮执行，更具体地说是由其颗粒层和角质层执行。与该功能相关的主要结构成分是细胞间脂质层、桥粒、角蛋白桥粒、紧密连接、角质细胞包膜和角蛋白丝。在这篇综述中，我们讨论了它们的超微结构、分子基础及其与皮肤疾病的相关性的最新知识。
