观点：血管生成的 MRI 研究
Perspectives: MRI of angiogenesis.
机构信息
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
出版信息
J Magn Reson. 2018 Jul;292:99-105. doi: 10.1016/j.jmr.2018.04.008. Epub 2018 Apr 12.
Angiogenesis, the expansion of the vascular bed, is an important component in remodeling of tissues and organs. Such remodeling is essential for coping with substantial and sustained increase in the demands for supply of oxygen and nutrients and the timely removal of waste products. The vasculature, and its effectiveness in systemic delivery to all parts of the body, regulates the distribution of immune cells and the delivery of therapeutics as well as the dissemination of disease. Therefore, the vascular bed is possibly one of the key organs involved in homeostasis, in health and disease. The critical role of the vasculature in health, and the accessibility to non invasive probing by MRI, renders MRI as a modality of choice for monitoring the vasculature and its adaption to challenges.
血管生成，即血管床的扩张，是组织和器官重塑的重要组成部分。这种重塑对于应对氧气和营养物质供应的大量持续增加以及及时清除废物是必不可少的。脉管系统及其向全身各部位输送的效率调节免疫细胞的分布以及治疗药物的输送以及疾病的传播。因此，血管床可能是参与体内平衡、健康和疾病的关键器官之一。脉管系统在健康中的关键作用以及通过 MRI 进行非侵入性探测的可及性，使得 MRI 成为监测血管及其对挑战的适应的首选方式。
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