基质蛋白 tenascin-C 扩增并可逆地阻断小鼠嗜酸性粒细胞前体的成熟。
Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors.
机构信息
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
出版信息
J Allergy Clin Immunol. 2018 Aug;142(2):695-698.e4. doi: 10.1016/j.jaci.2018.02.054. Epub 2018 Apr 27.
Abstract
We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix’s regulation of hematopoiesis has significant implications for targeting tissue eosinophils.
摘要
我们表明，哮喘相关细胞外基质糖蛋白 Tenascin-C 促进造血祖细胞，并抑制 IL-5 驱动的小鼠肺嗜酸性粒细胞的成熟。细胞外基质对造血的调节对靶向组织嗜酸性粒细胞具有重要意义。
相似文献
1
Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors.基质蛋白 tenascin-C 扩增并可逆地阻断小鼠嗜酸性粒细胞前体的成熟。
J Allergy Clin Immunol. 2018 Aug;142(2):695-698.e4. doi: 10.1016/j.jaci.2018.02.054. Epub 2018 Apr 27.
2
Extracellular matrix alterations in brains lacking four of its components.缺乏四种成分的大脑中的细胞外基质改变。
Biochem Biophys Res Commun. 2005 Mar 11;328(2):608-17. doi: 10.1016/j.bbrc.2005.01.026.
3
Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice.腱生蛋白-R和小白蛋白单敲除及双敲除小鼠中神经元周围网的形态学
Brain Res. 2000 May 2;864(1):142-5. doi: 10.1016/s0006-8993(00)02173-9.
4
The extracellular matrix glycoprotein Tenascin-C is expressed by oligodendrocyte precursor cells and required for the regulation of maturation rate, survival and responsiveness to platelet-derived growth factor.细胞外基质糖蛋白腱生蛋白-C由少突胶质前体细胞表达，是调节成熟速率、存活以及对血小板衍生生长因子反应性所必需的。
Eur J Neurosci. 2004 Nov;20(10):2524-40. doi: 10.1111/j.1460-9568.2004.03727.x.
5
Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition.腱生蛋白-X缺陷小鼠的伤口愈合表明，腱生蛋白-X参与基质成熟而非基质沉积。
Connect Tissue Res. 2007;48(2):93-8. doi: 10.1080/03008200601166160.
6
The neuronal extracellular matrix restricts distribution and internalization of aggregated Tau-protein.神经元细胞外基质限制聚集的 Tau 蛋白的分布和内化。
Neuroscience. 2016 Jan 28;313:225-35. doi: 10.1016/j.neuroscience.2015.11.040. Epub 2015 Nov 24.
7
Components of astrocytic extracellular matrix are regulated by contact with axons.星形胶质细胞细胞外基质的成分受与轴突接触的调节。
Ann N Y Acad Sci. 1991;633:566-9. doi: 10.1111/j.1749-6632.1991.tb15663.x.
8
Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.Tenascin C 和 tenascin R 同样以依赖 RhoA 的方式阻止髓鞘膜的形成，但通过独立的途径拮抗调节髓鞘碱性蛋白的表达。
Glia. 2009 Dec;57(16):1790-801. doi: 10.1002/glia.20891.
9
Altered distribution of extracellular matrix proteins in the periodontal ligament of periostin-deficient mice.骨膜蛋白缺陷小鼠牙周韧带中细胞外基质蛋白分布的改变
Histol Histopathol. 2014 Jun;29(6):731-42. doi: 10.14670/HH-29.731. Epub 2013 Dec 19.
10
Extracellular matrix alterations, accelerated leukocyte infiltration and enhanced axonal sprouting after spinal cord hemisection in tenascin-C-deficient mice.腱糖蛋白-C 缺失小鼠脊髓半切后细胞外基质改变、白细胞浸润加速和轴突发芽增强。
Acta Histochem. 2013 Oct;115(8):865-78. doi: 10.1016/j.acthis.2013.04.009. Epub 2013 May 21.
引用本文的文献
1
The twilight zone: plasticity and mixed ontogeny of neutrophil and eosinophil granulocyte subsets.暮光之区：中性粒细胞和嗜酸性粒细胞亚群的可塑性和混合个体发生。
Semin Immunopathol. 2021 Jun;43(3):337-346. doi: 10.1007/s00281-021-00862-z. Epub 2021 May 19.
2
Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil.超越白细胞介素-5：代谢重编程和基质支持是产生和维持长寿嗜酸性粒细胞所必需的。
Cells. 2021 Apr 6;10(4):815. doi: 10.3390/cells10040815.
3
More than neutrophils: Lin(+)Ly6G(+)IL-5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.不止于中性粒细胞：Lin(+)Ly6G(+)IL-5Rα(+) 多能髓系细胞（MMCs）在正常鼠骨髓中占优势，并保留向嗜酸性粒细胞和单核细胞分化的能力。
J Leukoc Biol. 2022 Jan;111(1):113-122. doi: 10.1002/JLB.1AB0519-170RR. Epub 2021 Apr 15.
4
"NETs and EETs, a Whole Web of Mess".中性粒细胞胞外陷阱与环氧二十碳三烯酸，一团乱麻
Microorganisms. 2020 Dec 4;8(12):1925. doi: 10.3390/microorganisms8121925.
5
Tenascin-C inactivation impacts lung structure and function beyond lung development.Tenascin-C 失活对肺结构和功能的影响超出了肺发育阶段。
Sci Rep. 2020 Mar 20;10(1):5118. doi: 10.1038/s41598-020-61919-x.
本文引用的文献
1
Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma.美泊利单抗可减少哮喘患者气道中的嗜酸性粒细胞数量，但不改变其功能表型。
Am J Respir Crit Care Med. 2017 Dec 1;196(11):1385-1395. doi: 10.1164/rccm.201611-2234OC.
2
Tenascin-C at a glance.腱生蛋白-C简介。
J Cell Sci. 2016 Dec 1;129(23):4321-4327. doi: 10.1242/jcs.190546. Epub 2016 Nov 10.
3
Brief Report: Alternative Splicing of Extra Domain A (EIIIA) of Fibronectin Plays a Tissue-Specific Role in Hematopoietic Homeostasis.简短报告：纤连蛋白额外结构域A（EIIIA）的可变剪接在造血稳态中发挥组织特异性作用。
Stem Cells. 2016 Aug;34(8):2263-8. doi: 10.1002/stem.2381. Epub 2016 May 4.
4
Skin tissue repair: Matrix microenvironmental influences.皮肤组织修复：基质微环境的影响
Matrix Biol. 2016 Jan;49:25-36. doi: 10.1016/j.matbio.2015.08.001. Epub 2015 Aug 14.
5
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.细胞外基质蛋白 tenascin-C 是骨髓微环境中造血再生所必需的。
Blood. 2012 Jun 7;119(23):5429-37. doi: 10.1182/blood-2011-11-393645. Epub 2012 May 2.
6
Survival of cord blood haematopoietic stem cells in a hyaluronan hydrogel for ex vivo biomimicry.透明质酸水凝胶中脐带血造血干细胞的体外仿生存活。
J Tissue Eng Regen Med. 2013 Nov;7(11):901-10. doi: 10.1002/term.1482. Epub 2012 Mar 31.
7
The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.造血干细胞和祖细胞上的整合素 α9β1：参与细胞黏附、增殖和分化。
Haematologica. 2009 Nov;94(11):1493-501. doi: 10.3324/haematol.2009.006072. Epub 2009 Jul 16.
8
Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma.新诊断的特应性和非特应性哮喘中的气道炎症和基底膜肌腱蛋白
Respir Med. 2003 Sep;97(9):1045-51. doi: 10.1016/s0954-6111(03)00136-7.
9
Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.在腱生蛋白-C的第三个III型纤连蛋白重复序列中鉴定整联蛋白α9β1的配体结合位点。
J Biol Chem. 1998 May 8;273(19):11423-8. doi: 10.1074/jbc.273.19.11423.
Zotero 插件