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基质蛋白 tenascin-C 扩增并可逆地阻断小鼠嗜酸性粒细胞前体的成熟。

Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors.

机构信息

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.

出版信息

J Allergy Clin Immunol. 2018 Aug;142(2):695-698.e4. doi: 10.1016/j.jaci.2018.02.054. Epub 2018 Apr 27.

DOI:10.1016/j.jaci.2018.02.054
PMID:29705244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6737931/
Abstract

We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix’s regulation of hematopoiesis has significant implications for targeting tissue eosinophils.

摘要

我们表明，哮喘相关细胞外基质糖蛋白 Tenascin-C 促进造血祖细胞，并抑制 IL-5 驱动的小鼠肺嗜酸性粒细胞的成熟。细胞外基质对造血的调节对靶向组织嗜酸性粒细胞具有重要意义。

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Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors.基质蛋白 tenascin-C 扩增并可逆地阻断小鼠嗜酸性粒细胞前体的成熟。
J Allergy Clin Immunol. 2018 Aug;142(2):695-698.e4. doi: 10.1016/j.jaci.2018.02.054. Epub 2018 Apr 27.
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本文引用的文献

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Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma.美泊利单抗可减少哮喘患者气道中的嗜酸性粒细胞数量，但不改变其功能表型。
Am J Respir Crit Care Med. 2017 Dec 1;196(11):1385-1395. doi: 10.1164/rccm.201611-2234OC.
2
Tenascin-C at a glance.腱生蛋白-C简介。
J Cell Sci. 2016 Dec 1;129(23):4321-4327. doi: 10.1242/jcs.190546. Epub 2016 Nov 10.
3
Brief Report: Alternative Splicing of Extra Domain A (EIIIA) of Fibronectin Plays a Tissue-Specific Role in Hematopoietic Homeostasis.简短报告：纤连蛋白额外结构域A（EIIIA）的可变剪接在造血稳态中发挥组织特异性作用。
Stem Cells. 2016 Aug;34(8):2263-8. doi: 10.1002/stem.2381. Epub 2016 May 4.
4
Skin tissue repair: Matrix microenvironmental influences.皮肤组织修复：基质微环境的影响
Matrix Biol. 2016 Jan;49:25-36. doi: 10.1016/j.matbio.2015.08.001. Epub 2015 Aug 14.
5
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.细胞外基质蛋白 tenascin-C 是骨髓微环境中造血再生所必需的。
Blood. 2012 Jun 7;119(23):5429-37. doi: 10.1182/blood-2011-11-393645. Epub 2012 May 2.
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Survival of cord blood haematopoietic stem cells in a hyaluronan hydrogel for ex vivo biomimicry.透明质酸水凝胶中脐带血造血干细胞的体外仿生存活。
J Tissue Eng Regen Med. 2013 Nov;7(11):901-10. doi: 10.1002/term.1482. Epub 2012 Mar 31.
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The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.造血干细胞和祖细胞上的整合素 α9β1：参与细胞黏附、增殖和分化。
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