缓解-复发型多发性硬化症女性患者有氧运动对细胞因子和脂肪细胞因子的急性反应。
Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis.
机构信息
Musculoskeletal Rehabilitation Research Center and Department of Neurology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Complement Ther Clin Pract. 2018 May;31:295-301. doi: 10.1016/j.ctcp.2018.03.004. Epub 2018 Mar 14.
OBJECTIVE
To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).
METHODS
Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.
RESULTS
Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.
CONCLUSION
After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.
目的
研究多发性硬化（MS）复发期和缓解期运动对细胞因子和脂肪因子的急性影响。
方法
将 30 名处于复发或缓解期的 MS 女性与 15 名健康对照者进行匹配。参与者以最大心率的 60-70%进行单次有氧运动。此外，招募了 5 名处于复发期的女性（对照复发组）且不接受任何干预。在运动前、运动后即刻、1 小时和 6 小时采集血样。
结果
健康人和 MS 缓解期患者对运动的 IL-10 和 TNF-α 反应水平相似。与基线相比，复发期患者的 TNF-α水平在运动后即刻显著降低。运动后即刻，复发组的瘦素水平显著降低。脂联素和 IL-6 组间无显著差异。
结论
复发后，运动不会引起炎症细胞因子反应，并暂时改善细胞因子和脂肪因子的平衡。
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