多发性硬化症患者促炎细胞因子产生从春季到夏季的转变。

A spring to summer shift of pro-inflammatory cytokine production in multiple sclerosis patients.

作者信息

Damasceno Alfredo, Moraes Adriel Santos, Farias Alessandro, Damasceno Benito Pereira, dos Santos Leonilda Maria Barbosa, Cendes Fernando

机构信息

Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil; Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas (UNICAMP), Campinas, Brazil.

Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas (UNICAMP), Campinas, Brazil.

出版信息

J Neurol Sci. 2016 Jan 15;360:37-40. doi: 10.1016/j.jns.2015.11.022. Epub 2015 Nov 12.

DOI:10.1016/j.jns.2015.11.022

PMID:26723969

Abstract

Higher MS relapse frequency is observed during warmer months in different regions, but evidence for an underlying immunological variation is lacking. Therefore, we investigated seasonal variations of cytokine production in relapsing-remitting MS patients. Twenty-one patients and eight controls had blood samples drawn in each season, evaluating for IL-10, IL-6, TNF-α and IFN-γ. The lowest levels of cytokine production were observed in spring samples, with a significant increase from spring to summer for most cytokines, and especially IFN-γ and TNF-α. This phenomenon may underlie the higher prevalence of clinical and subclinical MS activity observed in warmer months.

摘要

在不同地区，较高的多发性硬化症（MS）复发频率在温暖月份更为常见，但目前缺乏潜在免疫变化的证据。因此，我们研究了复发缓解型MS患者细胞因子产生的季节性变化。21例患者和8名对照在每个季节采集血样，检测白细胞介素-10（IL-10）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）。春季样本中细胞因子产生水平最低，大多数细胞因子从春季到夏季显著增加，尤其是IFN-γ和TNF-α。这一现象可能是温暖月份临床和亚临床MS活动患病率较高的原因。