Wolozin B, Scicutella A, Davies P
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461.
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6202-6. doi: 10.1073/pnas.85.16.6202.
ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68). The protein is present in the brains of patients with Alzheimer disease but is not detectable in normal adult brain tissue. We now report that ALZ-50-reactive neurons are found in normal fetal and neonatal human brain and in brain tissue from neonatal individuals with Down syndrome. Reactive neurons decrease sharply in number after age 2 and reappear in older individuals with Down syndrome and in patients with Alzheimer disease.
ALZ - 50是一种单克隆抗体，可识别表观分子量为68千道尔顿的蛋白质（A68）。该蛋白质存在于阿尔茨海默病患者的大脑中，但在正常成人大脑组织中无法检测到。我们现在报告，在正常胎儿和新生儿的人类大脑以及唐氏综合征新生儿的脑组织中发现了ALZ - 50反应性神经元。2岁以后，反应性神经元的数量急剧减少，并在老年唐氏综合征患者和阿尔茨海默病患者中再次出现。
