Goldgaber D, Lerman M I, McBride O W, Saffiotti U, Gajdusek D C
Science. 1987 Feb 20;235(4791):877-80. doi: 10.1126/science.3810169.
Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.
从一个成人人类脑互补DNA文库中，用与阿尔茨海默病脑淀粉样β肽前20个氨基酸对应的寡核苷酸探针分离出了四个克隆。测序克隆的开放阅读框编码97个氨基酸，包括该多肽的已知氨基酸序列。在哺乳动物脑和人类胸腺中检测到了3.5千碱基的信使RNA。该基因在进化过程中高度保守，并且已被定位到人类21号染色体上。
