Lee Seung Yup, Pakela Julia M, Hedrick Taylor L, Vishwanath Karthik, Helton Michael C, Chung Yooree, Kolodziejski Noah J, Stapels Christopher J, McAdams Daniel R, Fernandez Daniel E, Christian James F, O'Reilly Jameson, Farkas Dana, Ward Brent B, Feinberg Stephen E, Mycek Mary-Ann
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
Applied Physics Program, University of Michigan, Ann Arbor, MI 48109.
Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb;10054. doi: 10.1117/12.2252295. Epub 2017 Feb 14.
In reconstructive surgery, tissue perfusion/vessel patency is critical to the success of microvascular free tissue flaps. Early detection of flap failure secondary to compromise of vascular perfusion would significantly increase the chances of flap salvage. We have developed a compact, clinically-compatible monitoring system to enable automated, minimally-invasive, continuous, and quantitative assessment of flap viability/perfusion. We tested the system's continuous monitoring capability during extended non-recovery surgery using an porcine free flap model. Initial results indicated that the system could assess flap viability/perfusion in a quantitative and continuous manner. With proven performance, the compact form constructed with cost-effective components would make this system suitable for clinical translation.
在重建手术中,组织灌注/血管通畅对于游离微血管组织皮瓣的成功至关重要。早期检测因血管灌注受损导致的皮瓣失败将显著增加挽救皮瓣的几率。我们开发了一种紧凑的、临床兼容的监测系统,以实现对皮瓣活力/灌注的自动化、微创、连续和定量评估。我们使用猪游离皮瓣模型在长时间非恢复性手术期间测试了该系统的连续监测能力。初步结果表明,该系统能够以定量和连续的方式评估皮瓣活力/灌注。凭借已证实的性能,采用具有成本效益的组件构建的紧凑形式将使该系统适用于临床转化。