Doležalová Helena, Blechová Nicole, Petera Jiří
Klin Onkol. 2018 Spring;31(2):125-129. doi: 10.14735/amko2018125.
The prevalence of head and neck tumors has continually increased over the past decades, which is a serious medical and social problem. This study retrospectively assessed the quality of life of patients with early-stage oral cavity tumors after high-dose rate (HDR) brachytherapy.
Quality of life was evaluated in 14 patients with early-onset oral cavity tumors who underwent HDR brachytherapy at the Department of Oncology and Radiotherapy, University Hospital Hradec Kralove. The standardized EORTC QLQ-C30 and EORTC QLQ-H&N 35 questionnaires were used. Patients completed these questionnaires at 12 months after treatment.
The general health status was scored 70 points using the EORTC QLQ-C30 questionnaire. Fatigue, insomnia, loss of appetite, dyspnea, and financial problems were the most severe problems reported. The main problems identified by the EORTC QLQ-H&N 35 questionnaire were weight gain, coughing, pain, sticky saliva, and difficulties eating in public. On the contrary, patients did not significantly suffer weight loss, speech impairments, difficulties in mouth opening or swallowing, or sensory problems.
HDR brachytherapy is an effective treatment for early oral cancer that leaves patients with an acceptable quality of life. A prospective, multicentric study focused on the quality of life of patients with head and neck tumors is required.Key worlds: oral cancer - brachytherapy - quality of life This article was supported by grant PROGRES Q 40/13. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 17. 1. 2018Accepted: 4. 2. 2018.
在过去几十年中，头颈部肿瘤的患病率持续上升，这是一个严重的医学和社会问题。本研究回顾性评估了高剂量率（HDR）近距离放射治疗后早期口腔肿瘤患者的生活质量。
对14例在赫拉德茨克拉洛韦大学医院肿瘤放疗科接受HDR近距离放射治疗的早期口腔肿瘤患者的生活质量进行评估。使用标准化的欧洲癌症研究与治疗组织（EORTC）QLQ-C30和EORTC QLQ-H&N 35问卷。患者在治疗后12个月完成这些问卷。
使用EORTC QLQ-C30问卷评估，总体健康状况得分为70分。疲劳、失眠、食欲不振、呼吸困难和经济问题是报告的最严重问题。EORTC QLQ-H&N 35问卷确定的主要问题是体重增加、咳嗽、疼痛、唾液黏稠以及在公共场合进食困难。相反，患者没有明显出现体重减轻、言语障碍、张口或吞咽困难或感觉问题。
HDR近距离放射治疗是早期口腔癌的有效治疗方法，能使患者维持可接受的生活质量。需要开展一项针对头颈部肿瘤患者生活质量的前瞻性、多中心研究。关键词：口腔癌 - 近距离放射治疗 - 生活质量 本文得到了PROGRES Q 40/13项目的资助。作者声明他们在研究中使用的药物、产品或服务方面不存在潜在利益冲突。编辑委员会声明该手稿符合ICMJE对生物医学论文的建议。提交日期：2018年1月17日 接受日期：2018年2月4日
