Hammerlid E, Mercke C, Sullivan M, Westin T
Department of Otolaryngology and Head and Neck Surgery, Sahlgrenska University Hospital, Göteborg University, Sweden.
Oral Oncol. 1997 May;33(3):189-96. doi: 10.1016/s0964-1955(96)00069-3.
The aim of this longitudinal quality of life (QL) study, was to study tumour-related symptoms and treatment side-effects of patients with oral or oropharyngeal cancer and to determine whether an increased local dose of irradiation (brachytherapy affected QL. The European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30), a tumour-specific Head and Neck questionnaire and the Hospital Anxiety and Depression scale (HAD) were used repeatedly during 1 year. There were 105 patients, with a cumulative response rate of 89%. Most symptoms and problems were at their peak 2 or 3 months after the start of treatment. Nutrition and pain were found to be the major problems, and as many as 19-40% reported psychiatric distress. Patients having received additional brachytherapy did not report any increase in QL problems (except for pain) compared with those having had external radiation only. Quality of life does not seem to be affected by the increased irradiation local dose given when brachytherapy is included in the treatment regimen.
这项纵向生活质量（QL）研究的目的是，研究口腔或口咽癌患者的肿瘤相关症状及治疗副作用，并确定增加局部照射剂量（近距离放射治疗）是否会影响生活质量。在1年期间多次使用欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）、一份特定肿瘤的头颈问卷以及医院焦虑抑郁量表（HAD）。共有105例患者，累积应答率为89%。大多数症状和问题在治疗开始后2或3个月达到高峰。营养和疼痛被发现是主要问题，多达19%至40%的患者报告有精神困扰。与仅接受外照射的患者相比，接受额外近距离放射治疗的患者并未报告生活质量问题（疼痛除外）有任何增加。当近距离放射治疗纳入治疗方案时，增加的局部照射剂量似乎并未影响生活质量。
