Koç Zehra Pınar, Kara Pelin Özcan, Dağtekin Ahmet
Nuclear Medicine Department, Medical Faculty, Mersin University, Mersin, Turkey.
Neurosurgery Department, Medical Faculty, Mersin University, Mersin, Turkey.
CNS Oncol. 2018 Apr;7(2):CNS12. doi: 10.2217/cns-2017-0018. Epub 2018 Apr 30.
F-18 fluorodeoxyglucose (FDG) PET/CT has several advantages in diagnosis of cancer of unknown primary with reported incremental diagnostic value. In this study, we evaluated the patients who were presented with multiple brain metastasis and unknown primary tumor.
MATERIALS & METHODS: 31 patients (17 males, 14 females; mean: 56.1 ± 14.22 years old) with diagnosis of brain metastasis according to histopathology and/or MRI were included into this retrospective study.
The patients presented with hypermetabolic (n = 17; mean SUVmax: 11.6 ± 6.9) or hypometabolic brain lesions with additional different metastatic sites in 13 patients (mean SUVmax: 9.03 ± 4.02). The primary tumor was determined by FDG PET/CT in 20/26 patients (77%) (lung [n = 6], primary brain [n = 9], renal cell carcinoma [n = 2], skin [n = 1], breast [n = 1] and neuroendocrine tumor [n = 1]).
New generation multislice scanners may provide higher detection ratios. The detection rate of FDG PET/CT might be higher than previously reported according to this study.
F-18氟脱氧葡萄糖（FDG）PET/CT在不明原发癌的诊断中具有多项优势，且有报道称其具有递增的诊断价值。在本研究中，我们对出现多发脑转移且原发肿瘤不明的患者进行了评估。
本回顾性研究纳入了31例根据组织病理学和/或MRI诊断为脑转移的患者（17例男性，14例女性；平均年龄：56.1±14.22岁）。
患者出现代谢增高的脑病变（n = 17；平均SUVmax：11.6±6.9）或代谢减低的脑病变，另有13例患者存在不同的转移部位（平均SUVmax：9.03±4.02）。26例患者中有20例（77%）通过FDG PET/CT确定了原发肿瘤（肺癌[n = 6]、原发性脑肿瘤[n = 9]、肾细胞癌[n = 2]、皮肤癌[n = 1]、乳腺癌[n = 1]和神经内分泌肿瘤[n = 1]）。
新一代多层螺旋扫描仪可能提供更高的检出率。根据本研究，FDG PET/CT的检出率可能高于先前报道。
