Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Dermatol Ther. 2018 May;31(3):e12595. doi: 10.1111/dth.12595. Epub 2018 Apr 30.
Topical application of timolol cream is effective and convenient for treating superficial infantile hemangiomas. Intralesional injection of corticosteroids, such as diprospan, is useful for the treatment of superficia infantile hemangiomas without systemic side effects. We conducted a self-controlled study to investigate whether a combination of intralesional injection of diprospan with topical timolol 0.5% cream would be more efficient than timolol cream alone in thick superficial infantile hemangiomas. Thirty-eight patients with 39 thick superficial infantile hemangiomas were recruited. Each lesion was randomly divided into two equal parts: one part was treated with topical timolol 0.5% cream (timolol cream group), while the other part was treated with injection of diprospan combined with topical timolol 0.5% cream (combined treatment group). Infants were followed every 4 weeks to determine whether injections should be continued, and timolol cream was applied four times daily for 5 months. During 5 months of treatment, three specialist physicians were invited to evaluate the therapeutic effects. The combined treatment group showed better lesion involution than did the timolol cream group regarding lesion thickness and color of lesions. The combination of intralesional injection of diprospan with topical timolol 0.5% cream is a suitable and safe strategy for thick superficial infantile hemangiomas.
局部应用噻吗洛尔乳膏治疗浅表婴幼儿血管瘤有效且方便。皮质类固醇如得宝松的瘤内注射对于治疗无全身副作用的浅表婴幼儿血管瘤是有用的。我们进行了一项自身对照研究，以探讨在厚的浅表婴幼儿血管瘤中，与单独使用噻吗洛尔乳膏相比，联合使用得宝松瘤内注射与局部使用 0.5%噻吗洛尔乳膏是否更有效。共招募了 38 名患有 39 个厚的浅表婴幼儿血管瘤的患者。每个病变随机分为两等份：一部分用 0.5%噻吗洛尔乳膏（噻吗洛尔乳膏组）局部治疗，另一部分用得宝松联合 0.5%噻吗洛尔乳膏局部治疗（联合治疗组）。每 4 周随访一次以确定是否需要继续注射，并用 0.5%噻吗洛尔乳膏每日 4 次应用 5 个月。在 5 个月的治疗期间，邀请了 3 名专家医生评估治疗效果。在病变厚度和病变颜色方面，联合治疗组的病变消退情况优于噻吗洛尔乳膏组。得宝松瘤内注射联合局部应用 0.5%噻吗洛尔乳膏是治疗厚的浅表婴幼儿血管瘤的一种合适且安全的策略。
