Szymczak Izabela, Pawliczak Rafal
Immunopathology Department; Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.
Adv Respir Med. 2018;86(2):103-109. doi: 10.5603/ARM.2018.0015.
Asthma - a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients. Thus, it provides positive relation between vitamin D and asthma. Increased prevalence of asthma over the past decades causes elevated interest in vitamin D supplementation that is even reported as a ,,potential therapeutic option''. Unfortunately, results of clinical trials are inconsistent and do not provide supportive information about positive role of vitamin D in asthma. Little or even no effect of supplementation of vitamin D in improvement of onset, symptoms or progression of asthma was found in comprehensive interventional studies in adults, children and pregnant woman. This review critically summarized the last years evidence of a relation between vitamin D and asthma in adults, children and pregnant women.
哮喘——一种与气道高反应性和炎症增加相关的慢性呼吸道疾病；影响着全球数百万人。维生素D具有抗炎和免疫调节活性。其缺乏（血清水平低于20 ng/mL）被发现与包括细菌和病毒感染以及哮喘在内的肺部疾病的发生有关。一些研究表明，血清中维生素D水平低与肺功能下降、气道炎症增加以及哮喘患者的总体不良结果有关。因此，这表明维生素D与哮喘之间存在正相关关系。在过去几十年中，哮喘患病率的上升引发了人们对补充维生素D的更高兴趣，甚至有报道称其为“潜在的治疗选择”。不幸的是，临床试验结果并不一致，并未提供关于维生素D在哮喘中积极作用的支持性信息。在针对成年人、儿童和孕妇的综合干预研究中，发现补充维生素D对改善哮喘的发作、症状或进展几乎没有或甚至没有效果。本综述批判性地总结了近年来关于成年人、儿童和孕妇中维生素D与哮喘关系的证据。
