Zhu Yidan, Blumenthal James A, Shi Chuan, Jiang Ronghuan, Patel Anushka, Zhang Aihua, Yu Xin, Gao Runlin, Wu Yangfeng
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina.
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina.
Am J Cardiol. 2018 Jun 15;121(12):1456-1460. doi: 10.1016/j.amjcard.2018.02.031. Epub 2018 Mar 13.
Although there is good evidence that sedentary behavior is associated with poor health outcomes in healthy persons and patients with cardiovascular disease, the mental health consequences of sedentary behavior have not been widely studied. In this report, we conducted a cross-sectional analysis to examine the relation of self-reported sedentary behavior and depression in a sample of 4,043 hospitalized men and women with acute coronary syndrome enrolled in a randomized clinical trial in rural China. Sedentary behavior was assessed by self-report, and depression was assessed with the Patient Health Questionnaire-9 (PHQ-9); a subset of 1,209 patients also completed the Beck Depression Inventory-II. Results revealed that greater sedentary behavior was associated with higher levels of depressive symptoms measured by both the PHQ-9 (p <0.001) and the Beck Depression Inventory-II (p <0.001). Compared with patients who reported that they were seldom sedentary, patients reporting that they were frequently sedentary were 4.7 times (odds ratio 4.73, 95% confidence interval 2.71 to 8.24) more likely to be clinically depressed defined as PHQ-9 scores ≥10 after adjusting for demographic factors, lifestyle behaviors, clinical characteristics, and in-hospital treatments. In conclusion, greater sedentary behavior is significantly related to greater depression in Chinese patients with acute coronary syndrome, independent of physical activity. These findings suggest that strategies to reduce sedentary behavior may improve medical outcomes and reduce risk for depression.
尽管有充分证据表明，久坐行为与健康人群及心血管疾病患者的不良健康结局相关，但久坐行为对心理健康的影响尚未得到广泛研究。在本报告中，我们进行了一项横断面分析，以检验在中国农村一项随机临床试验中纳入的4043例急性冠状动脉综合征住院男女样本中，自我报告的久坐行为与抑郁之间的关系。久坐行为通过自我报告进行评估，抑郁通过患者健康问卷-9（PHQ-9）进行评估；1209例患者的一个子集还完成了贝克抑郁量表-II。结果显示，久坐行为越多，通过PHQ-9（p＜0.001）和贝克抑郁量表-II（p＜0.001）测得的抑郁症状水平越高。在调整了人口统计学因素、生活方式行为、临床特征和住院治疗后，与报告很少久坐的患者相比，报告经常久坐的患者临床抑郁（定义为PHQ-9评分≥10）的可能性高4.7倍（比值比4.73，95%置信区间2.71至8.24）。总之，在中国急性冠状动脉综合征患者中，久坐行为越多与抑郁程度越高显著相关，且与体力活动无关。这些发现表明，减少久坐行为的策略可能会改善医疗结局并降低抑郁风险。
