Kirstein C L, Spear L P
Department of Psychology, SUNY-Binghamton, NY 13901.
Eur J Pharmacol. 1988 Jun 10;150(3):339-45. doi: 10.1016/0014-2999(88)90016-7.
Sprague-Dawley rat pups at 3-4 days prenatally were tested in both the absence and presence of milk following administration of various doses of either the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), the 5-HT1B agonist 1-(3-chlorophenyl)piperazine (mCPP), or the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Administration of 8-OHDPAT decreased mouthing, increased probing and increased behavioral activation. Conversely, the 5-HT2 agonist DOI and the 5-HT1B agonist mCPP increased mouthing and decreased probing. mCPP and DOI differed in their effects on behavioral activation, with mCPP decreasing and DOI increasing this composite behavioral score. mCPP increased grooming, whereas DOI elicited a characteristic unusual positioning of the limbs. Thus it appears that 5-HT1A, 5-HT1B and 5-HT2 receptor subtypes are present in the neonate and elicit differential behavioral responses upon stimulation with selective agonists. Ontogenetic variations in the balance among these receptor subtypes during development may be related to the ontogenetic reversal that has been previously reported in the impact of serotonin manipulations on mouthing and suckling behavior during the neonatal to weanling age period.
在产前3 - 4天的斯普拉格-道利大鼠幼崽中，在给予不同剂量的5 - 羟色胺1A受体激动剂8 - 羟基-2 -（二正丙基氨基）四氢萘（8 - OHDPAT）、5 - 羟色胺1B受体激动剂1 -（3 - 氯苯基）哌嗪（mCPP）或5 - 羟色胺2受体激动剂1 -（2,5 - 二甲氧基-4 - 碘苯基）-2 - 氨基丙烷（DOI）后，分别在有无乳汁的情况下进行测试。给予8 - OHDPAT会减少口部动作、增加探究行为并增强行为激活。相反，5 - 羟色胺2受体激动剂DOI和5 - 羟色胺1B受体激动剂mCPP会增加口部动作并减少探究行为。mCPP和DOI对行为激活的影响不同，mCPP会降低而DOI会增加这种综合行为评分。mCPP增加梳理行为，而DOI会引发四肢的一种特征性异常姿势。因此，似乎5 - 羟色胺1A、5 - 羟色胺1B和5 - 羟色胺2受体亚型存在于新生儿中，并且在用选择性激动剂刺激时会引发不同的行为反应。在发育过程中这些受体亚型之间平衡的个体发生变化可能与先前报道的在新生儿到断奶期血清素操纵对口部动作和吸吮行为影响中的个体发生逆转有关。
