Hollema H, Poppema S
Department of Pathology, University of Groningen, The Netherlands.
Hum Pathol. 1988 Sep;19(9):1053-9. doi: 10.1016/s0046-8177(88)80086-8.
Five cases of intermediate lymphocytic lymphoma (ILL), 13 cases of malignant lymphoma centrocytic (MLCC), and 27 cases of malignant lymphoma centroblastic centrocytic (MLCBCC) were studied morphologically and with the aid of a panel of monoclonal antibodies. The immunophenotypes of ILL and MLCC (IgM+/IgD+, MT1+, CALLA-) indicate a mantle zone or very early follicle center derivation. The immunophenotypes of MLCBCC (IgM+ or IgG/IgA+, MT1-, CALLA+) indicate a "true" follicle center derivation. The morphologic diversity of MLCBCC could not be related to specific immunophenotypes.
对5例中等淋巴细胞淋巴瘤（ILL）、13例中心细胞性恶性淋巴瘤（MLCC）和27例中心母细胞中心细胞性恶性淋巴瘤（MLCBCC）进行了形态学研究，并借助一组单克隆抗体进行分析。ILL和MLCC的免疫表型（IgM+/IgD+、MT1+、CALLA-）表明其起源于套区或非常早期的滤泡中心。MLCBCC的免疫表型（IgM+或IgG/IgA+、MT1-、CALLA+）表明其起源于“真正的”滤泡中心。MLCBCC的形态学多样性与特定的免疫表型无关。
