Harris N L, Bhan A K
Am J Surg Pathol. 1985 Dec;9(12):872-82.
We analyzed the distribution and immunologic phenotype of the neoplastic cells in eight cases of mantle-zone lymphoma. Although in all the cases the follicle centers appeared reactive on routine histologic examination, polyclonal staining for immunoglobulin was found in the follicle centers in only five of the eight cases; in the other three cases the follicle centers were monoclonal. In three cases, the immunologic phenotype was that of centrocytic (diffuse small cleaved cell) lymphoma: IgM+IgD+B1+B2+Ia+Tl+. In one case the phenotype was that of a follicular (centroblastic/centrocytic) lymphoma: IgG+B1+B2+Ia+CALLA+. In the other four cases, the phenotype was IgM+B1+B2+ or B2-Ia+; this phenotype can be seen in diverse B cell lymphomas. The phenotype of normal mantle-zone cells (IgM+IgD+B1+B2+Ia+) was not reproduced by any of the lymphomas. A mantle-zone pattern may be produced by either follicular or diffuse lymphomas of predominantly small cleaved cell type, and does not indicate an origin from the cells of the normal mantle zone.
我们分析了8例套区淋巴瘤肿瘤细胞的分布及免疫表型。尽管在所有病例中，滤泡中心在常规组织学检查时表现为反应性，但8例中仅5例的滤泡中心免疫球蛋白呈多克隆染色；另外3例的滤泡中心为单克隆。3例的免疫表型为中心细胞性（弥漫性小裂细胞）淋巴瘤：IgM+IgD+B1+B2+Ia+Tl+。1例的表型为滤泡性（中心母细胞性/中心细胞性）淋巴瘤：IgG+B1+B2+Ia+CALLA+。其他4例的表型为IgM+B1+B2+或B2-Ia+；这种表型可见于多种B细胞淋巴瘤。正常套区细胞的表型（IgM+IgD+B1+B2+Ia+）在任何一种淋巴瘤中均未重现。套区模式可由主要为小裂细胞型的滤泡性或弥漫性淋巴瘤产生，并不表明起源于正常套区的细胞。
