β-高丙氨酰肽核酸类似物：高阶结构的合成与表征
β-Homoalanyl PNAs: Synthesis and Indication of Higher Ordered Structures.
作者信息
Diederichsen Ulf, Schmitt Harald W
机构信息
Institut für Organische Chemie und Biochemie der Technischen Universität München, Lichtenbergstrasse 4, D-85747 Garching (Germany), Fax: Int. code+(49) 89 2891-3210.
出版信息
Angew Chem Int Ed Engl. 1998 Feb 16;37(3):302-305. doi: 10.1002/(SICI)1521-3773(19980216)37:3<302::AID-ANIE302>3.0.CO;2-4.
Abstract
Self-pairing complexes with extraordinarily high stability are formed by β-PNAs with four to six units of the nucleo-β-amino acid 1. The key step in the synthesis is a Mitsunobu reaction between a β-homoserine and a purine derivative.
摘要
由含有4至6个核-β-氨基酸1单元的β-肽核酸形成具有极高稳定性的自配对复合物。合成中的关键步骤是β-高丝氨酸与嘌呤衍生物之间的 Mitsunobu 反应。
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