Base-Catalyzed Synthesis of N-(2-Arylethyl)anilines and Base-Promoted Domino Synthesis of 2,3-Dihydroindoles.
作者信息
Beller Matthias, Breindl Claudia, Riermeier Thomas H, Eichberger Martin, Trauthwein Harald
机构信息
Institut für Organische Katalyseforschung (IfOK), an der Universität Rostock e.V., Buchbinderstraße 5-6, D-18055 Rostock (Germany), Fax: (+49) 381-4669324.
Lehrstuhl für Anorganische Chemie, der Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching (Germany), Fax: (+49) 89-289-13473.
出版信息
Angew Chem Int Ed Engl. 1998 Dec 31;37(24):3389-3391. doi: 10.1002/(SICI)1521-3773(19981231)37:24<3389::AID-ANIE3389>3.0.CO;2-D.
The base is the key to the new one-pot reaction, which leads to pharmacologically interesting 2,3-dihydroindoles. The use of potassium tert-butylalcoholate enables the selective addition of primary anilines to substituted styrenes and a new domino reaction, consisting of a hydroamination and an aryne cyclization (see scheme).
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