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原发性高血压患者的家庭血压最大值与左心房直径相关。

Maximum home blood pressure readings are associated with left atrial diameter in essential hypertensives.

机构信息

Department of Cardiology, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

出版信息

J Hum Hypertens. 2018 Jun;32(6):432-439. doi: 10.1038/s41371-018-0060-3. Epub 2018 May 1.

Abstract

We tested the hypothesis that the maximum value of home systolic BP (MSBP) is a marker of hypertensive target organ damage (TOD). We conducted a cross-sectional study of 220 hypertensives. The subjects performed HBP monitoring using a telemonitoring system and measured their HBP for 7 days. Mean, maximum, standard deviation, and coefficient of variation of SBPs were used as independent variables. Brachial-ankle pulse wave velocity, left ventricular mass index (LVMI), mean carotid intima-media thickness, and left atrial diameter index (LADI) were used as dependent variables. Mean and maximum SBPs were significantly associated with each TOD marker. MSBP showed a significantly stronger association with LADI compared to mean SBP (p = 0.0012) and a significant relationship with LADI independent of LVMI (p = 0.024). Our findings suggest that MSBP is associated with TOD measures, similar to mean SBP. These results may indicate that MSBP could be a target of intervention for patients with atrial fibrillation.

摘要

我们检验了假设,即家庭收缩压(MSBP)的最大值是高血压靶器官损伤(TOD)的标志物。我们对 220 名高血压患者进行了横断面研究。受试者使用远程监测系统进行 HBP 监测,并测量了他们的 HBP 7 天。SBP 的平均值、最大值、标准差和变异系数作为自变量。肱踝脉搏波速度、左心室质量指数(LVMI)、颈动脉平均内膜中层厚度和左心房直径指数(LADI)作为因变量。平均 SBP 和最大 SBP 与每个 TOD 标志物均显著相关。MSBP 与 LADI 的相关性明显强于平均 SBP(p=0.0012),并且与 LVMI 无关与 LADI 有显著关系(p=0.024)。我们的研究结果表明,MSBP 与 TOD 测量值有关,与平均 SBP 相似。这些结果可能表明 MSBP 可能成为房颤患者干预的靶点。

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