Department of Cardiology, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
J Hum Hypertens. 2018 Jun;32(6):432-439. doi: 10.1038/s41371-018-0060-3. Epub 2018 May 1.
We tested the hypothesis that the maximum value of home systolic BP (MSBP) is a marker of hypertensive target organ damage (TOD). We conducted a cross-sectional study of 220 hypertensives. The subjects performed HBP monitoring using a telemonitoring system and measured their HBP for 7 days. Mean, maximum, standard deviation, and coefficient of variation of SBPs were used as independent variables. Brachial-ankle pulse wave velocity, left ventricular mass index (LVMI), mean carotid intima-media thickness, and left atrial diameter index (LADI) were used as dependent variables. Mean and maximum SBPs were significantly associated with each TOD marker. MSBP showed a significantly stronger association with LADI compared to mean SBP (p = 0.0012) and a significant relationship with LADI independent of LVMI (p = 0.024). Our findings suggest that MSBP is associated with TOD measures, similar to mean SBP. These results may indicate that MSBP could be a target of intervention for patients with atrial fibrillation.
我们检验了假设,即家庭收缩压(MSBP)的最大值是高血压靶器官损伤(TOD)的标志物。我们对 220 名高血压患者进行了横断面研究。受试者使用远程监测系统进行 HBP 监测,并测量了他们的 HBP 7 天。SBP 的平均值、最大值、标准差和变异系数作为自变量。肱踝脉搏波速度、左心室质量指数(LVMI)、颈动脉平均内膜中层厚度和左心房直径指数(LADI)作为因变量。平均 SBP 和最大 SBP 与每个 TOD 标志物均显著相关。MSBP 与 LADI 的相关性明显强于平均 SBP(p=0.0012),并且与 LVMI 无关与 LADI 有显著关系(p=0.024)。我们的研究结果表明,MSBP 与 TOD 测量值有关,与平均 SBP 相似。这些结果可能表明 MSBP 可能成为房颤患者干预的靶点。